BIOD 331 Module 5 Exam: Respiratory Pathophysiology 2026/2027
UPDATE
1. Which antibody is primarily associated with the Type I hypersensitivity
reaction observed in extrinsic asthma?
A. IgG
B. IgA
C. IgE
D. IgM
Answer: C
Rationale: IgE is the primary antibody involved in the allergic response of extrinsic
(atopic) asthma, binding to mast cells and triggering degranulation.
2. Which of the following is a classic clinical manifestation of emphysema, often
referred to as a ‘Pink Puffer’?
A. Productive cough for 3 months
B. Cyanosis and peripheral edema
C. Barrel chest due to air trapping
D. Purulent sputum production
Answer: C
Rationale: Emphysema patients often develop a barrel chest due to hyperinflation and air
trapping within the damaged alveoli.
,3. What is the primary underlying cause of Alpha-1 Antitrypsin deficiency
related emphysema?
A. Genetic predisposition
B. Chronic smoking
C. Bacterial infection
D. Occupational dust exposure
Answer: A
Rationale: Alpha-1 Antitrypsin deficiency is a genetic disorder where the lack of this
enzyme leads to uninhibited breakdown of lung tissue by proteases.
4. In Chronic Bronchitis, what is the defining clinical criteria for diagnosis?
A. FEV1/FVC ratio less than 0.5
B. Presence of Ghon complexes on X-ray
C. Productive cough for 3 months in 2 consecutive years
D. Refractory hypoxemia with PEEP
Answer: C
Rationale: Chronic Bronchitis is clinically defined as a productive cough lasting at least 3
months over at least 2 consecutive years.
5. Which stage of pneumonia is characterized by the accumulation of fibrin and
red blood cells in the alveolar exudate, making the lung appear liver-like?
A. Congestion
B. Resolution
C. Gray Hepatization
D. Red Hepatization
Answer: D
Rationale: During Red Hepatization, the alveoli fill with RBCs, neutrophils, and fibrin,
giving the lung a solid, red appearance similar to the liver.
, 6. Acute Respiratory Distress Syndrome (ARDS) is primarily characterized by
which of the following?
A. Increased pulmonary compliance
B. Decreased capillary permeability
C. Hypoxemia refractory to oxygen therapy
D. Excessive surfactant production
Answer: C
Rationale: A hallmark of ARDS is refractory hypoxemia, where blood oxygen levels remain
low despite administration of high concentrations of supplemental oxygen.
7. Which component of Virchow’s Triad is most directly involved when a patient
develops a pulmonary embolism after a long-duration flight?
A. Endothelial injury
B. Venous stasis
C. Vessel wall inflammation
D. Increased cardiac output
Answer: B
Rationale: Prolonged immobility during travel causes venous stasis, which is a key factor
in the formation of deep vein thromboses that can lead to pulmonary embolism.
8. What is the primary gas exchange abnormality found in a patient with a
massive Pulmonary Embolism?
A. Ventilation/Perfusion (V/Q) Shunt
B. Increased Diffusion Capacity
C. Hypoventilation
D. Alveolar Dead Space
Answer: D
Rationale: Pulmonary embolism causes Alveolar Dead Space, where areas of the lung are
ventilated but not perfused due to the blockage in the blood vessel.
UPDATE
1. Which antibody is primarily associated with the Type I hypersensitivity
reaction observed in extrinsic asthma?
A. IgG
B. IgA
C. IgE
D. IgM
Answer: C
Rationale: IgE is the primary antibody involved in the allergic response of extrinsic
(atopic) asthma, binding to mast cells and triggering degranulation.
2. Which of the following is a classic clinical manifestation of emphysema, often
referred to as a ‘Pink Puffer’?
A. Productive cough for 3 months
B. Cyanosis and peripheral edema
C. Barrel chest due to air trapping
D. Purulent sputum production
Answer: C
Rationale: Emphysema patients often develop a barrel chest due to hyperinflation and air
trapping within the damaged alveoli.
,3. What is the primary underlying cause of Alpha-1 Antitrypsin deficiency
related emphysema?
A. Genetic predisposition
B. Chronic smoking
C. Bacterial infection
D. Occupational dust exposure
Answer: A
Rationale: Alpha-1 Antitrypsin deficiency is a genetic disorder where the lack of this
enzyme leads to uninhibited breakdown of lung tissue by proteases.
4. In Chronic Bronchitis, what is the defining clinical criteria for diagnosis?
A. FEV1/FVC ratio less than 0.5
B. Presence of Ghon complexes on X-ray
C. Productive cough for 3 months in 2 consecutive years
D. Refractory hypoxemia with PEEP
Answer: C
Rationale: Chronic Bronchitis is clinically defined as a productive cough lasting at least 3
months over at least 2 consecutive years.
5. Which stage of pneumonia is characterized by the accumulation of fibrin and
red blood cells in the alveolar exudate, making the lung appear liver-like?
A. Congestion
B. Resolution
C. Gray Hepatization
D. Red Hepatization
Answer: D
Rationale: During Red Hepatization, the alveoli fill with RBCs, neutrophils, and fibrin,
giving the lung a solid, red appearance similar to the liver.
, 6. Acute Respiratory Distress Syndrome (ARDS) is primarily characterized by
which of the following?
A. Increased pulmonary compliance
B. Decreased capillary permeability
C. Hypoxemia refractory to oxygen therapy
D. Excessive surfactant production
Answer: C
Rationale: A hallmark of ARDS is refractory hypoxemia, where blood oxygen levels remain
low despite administration of high concentrations of supplemental oxygen.
7. Which component of Virchow’s Triad is most directly involved when a patient
develops a pulmonary embolism after a long-duration flight?
A. Endothelial injury
B. Venous stasis
C. Vessel wall inflammation
D. Increased cardiac output
Answer: B
Rationale: Prolonged immobility during travel causes venous stasis, which is a key factor
in the formation of deep vein thromboses that can lead to pulmonary embolism.
8. What is the primary gas exchange abnormality found in a patient with a
massive Pulmonary Embolism?
A. Ventilation/Perfusion (V/Q) Shunt
B. Increased Diffusion Capacity
C. Hypoventilation
D. Alveolar Dead Space
Answer: D
Rationale: Pulmonary embolism causes Alveolar Dead Space, where areas of the lung are
ventilated but not perfused due to the blockage in the blood vessel.
