BIOM 3090 CNS Pharmacology Exam Questions With Complete Solutions.

BIOM 3090 CNS Pharmacology Exam
Questions With Complete Solutions


Glutamate
- Acts on NMDA and non-NMDA receptors
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- NMDA receptor = ion channel (↑Ca2+, Na+, K+)
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- Excitatory Neurotransmitter
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GABA
- Acts on GABA receptors
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- GABA(A) = ion channel (↑Cl-)
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- GABA (B) = G-protein linked to ion channel (↑K+)
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- Inhibitory Neurotransmitter
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Acetylcholine
Receptor types and effect
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- M1, M3, M5: G-protein: ↑ IP3, DAG, K+ conductance
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- M2, M4: G-protein: ↓ cAMP
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, - N: ion channel: ↑ Na+, K+ conductance
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- Mixed action neurotransmitter
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Norepinephrine
Receptor types and effect | | |




- ⍺1: G-protein: ↑ IP3, DAG, ↓ K+ conductance
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- ⍺2: G-protein: ↓ cAMP (inhibitory)
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- β1, β2: G-protein: ↑cAMP
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- Mixed action neurotransmitter
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Dopamine
- Acts on dopamine receptor (D2 is the important one and one
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mechanism written for | |




- D2: G-protein: ↓ Ca2+ conductance (presynaptic)
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- D2: G-protein: ↑ K+ conductance, (postsynaptic)
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Serotonin
- Acts on 5-HT(2A)
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