BIOM 3090 Midterm (Units 1-3) Exam
Questions With Correct Answers
Pharmacokinetics - CORRECT ANSWER✔✔-describes how the body | | | | | | |
affects a specific drug
| | |
Bioavailability - CORRECT ANSWER✔✔-the amount of an administered
| | | | | | | |
dose of drug that reaches systemic circulation
| | | | | |
Bioavailability = quantity of drug reaching systemic circulation / quantity
| | | | | | | | |
of drug administered
| | |
pKa - CORRECT ANSWER✔✔-the ionization constant for acids and bases
| | | | | | | | | |
and is equal to the pH at which 50% of the drug is ionized
| | | | | | | | | | | | |
Henderson-Hasselbalch Equation - CORRECT ANSWER✔✔-pKa - pH = log | | | | | | | |
(protonated/unprotonated)
|
Which side of the membrane do drugs accumulate? - CORRECT
| | | | | | | | | |
ANSWER✔✔-The side where ionization is highest | | | | |
,Which fluids do basic drugs accumulate in? - CORRECT ANSWER✔✔-
| | | | | | | | |
Acidic fluids |
Which fluids do acidic drugs accumulate in? - CORRECT ANSWER✔✔-
| | | | | | | | |
Basic fluids
|
What is the simplest drug route? - CORRECT ANSWER✔✔-Oral
| | | | | | | |
What are the advantages of oral administration? - CORRECT
| | | | | | | | |
ANSWER✔✔-- simple & convenient | | |
- safer than injections
| | |
- painless
|
What are the disadvantages of oral administration - CORRECT
| | | | | | | | |
ANSWER✔✔-- absorption may be erratic | | | |
- patient compliance issues
| | |
- slow delivery
| |
- first pass effect
| | |
What is the first pass effect? - CORRECT ANSWER✔✔-When liver
| | | | | | | | | |
enzymes inactive a portion of the ingested drug and the dosage may be
| | | | | | | | | | | | |
altered
, What are the 6 parenteral drug routes? - CORRECT ANSWER✔✔-1.
| | | | | | | | | |
Subcutaneous injection (SC) | |
2. Intramuscular injection (IM)
| | |
3. Intravenous injection (IV)
| | |
4. Sublingual
|
5. Topical
| |
6. Transdermal
|
What are the advantages of SC administration? - CORRECT
| | | | | | | | |
ANSWER✔✔-- Easier than IV | | |
- Absorption is slower than IV or IM
| | | | | | |
- Suitable for solid pellets, insoluble suspensions
| | | | | |
What are the disadvantages of SC administration? - CORRECT
| | | | | | | | |
ANSWER✔✔-- Not for large volumes | | | |
- Could be painful
| | |
- Absorption can be very slow
| | | | |
- Infection may occur
| | |
What are the advantages of IM route? - CORRECT ANSWER✔✔-- Good
| | | | | | | | | | |
for moderate volumes
| |
- Safer and easier than IV
| | | | |
Questions With Correct Answers
Pharmacokinetics - CORRECT ANSWER✔✔-describes how the body | | | | | | |
affects a specific drug
| | |
Bioavailability - CORRECT ANSWER✔✔-the amount of an administered
| | | | | | | |
dose of drug that reaches systemic circulation
| | | | | |
Bioavailability = quantity of drug reaching systemic circulation / quantity
| | | | | | | | |
of drug administered
| | |
pKa - CORRECT ANSWER✔✔-the ionization constant for acids and bases
| | | | | | | | | |
and is equal to the pH at which 50% of the drug is ionized
| | | | | | | | | | | | |
Henderson-Hasselbalch Equation - CORRECT ANSWER✔✔-pKa - pH = log | | | | | | | |
(protonated/unprotonated)
|
Which side of the membrane do drugs accumulate? - CORRECT
| | | | | | | | | |
ANSWER✔✔-The side where ionization is highest | | | | |
,Which fluids do basic drugs accumulate in? - CORRECT ANSWER✔✔-
| | | | | | | | |
Acidic fluids |
Which fluids do acidic drugs accumulate in? - CORRECT ANSWER✔✔-
| | | | | | | | |
Basic fluids
|
What is the simplest drug route? - CORRECT ANSWER✔✔-Oral
| | | | | | | |
What are the advantages of oral administration? - CORRECT
| | | | | | | | |
ANSWER✔✔-- simple & convenient | | |
- safer than injections
| | |
- painless
|
What are the disadvantages of oral administration - CORRECT
| | | | | | | | |
ANSWER✔✔-- absorption may be erratic | | | |
- patient compliance issues
| | |
- slow delivery
| |
- first pass effect
| | |
What is the first pass effect? - CORRECT ANSWER✔✔-When liver
| | | | | | | | | |
enzymes inactive a portion of the ingested drug and the dosage may be
| | | | | | | | | | | | |
altered
, What are the 6 parenteral drug routes? - CORRECT ANSWER✔✔-1.
| | | | | | | | | |
Subcutaneous injection (SC) | |
2. Intramuscular injection (IM)
| | |
3. Intravenous injection (IV)
| | |
4. Sublingual
|
5. Topical
| |
6. Transdermal
|
What are the advantages of SC administration? - CORRECT
| | | | | | | | |
ANSWER✔✔-- Easier than IV | | |
- Absorption is slower than IV or IM
| | | | | | |
- Suitable for solid pellets, insoluble suspensions
| | | | | |
What are the disadvantages of SC administration? - CORRECT
| | | | | | | | |
ANSWER✔✔-- Not for large volumes | | | |
- Could be painful
| | |
- Absorption can be very slow
| | | | |
- Infection may occur
| | |
What are the advantages of IM route? - CORRECT ANSWER✔✔-- Good
| | | | | | | | | | |
for moderate volumes
| |
- Safer and easier than IV
| | | | |
