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i-Human Comprehensive Case Study: Nina Adams (45 y/o Female) Fatigue & Arm Weakness

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The file outlines objective physical exam findings, documenting right proximal muscle weakness (4/5 shoulder abduction and elbow flexion), diminished right biceps and triceps reflexes, and visible fatigability during repeated arm abduction testing (p. 7). It guides students through complex differential diagnoses—including Multiple Sclerosis, Myasthenia Gravis, Cervical Radiculopathy, and Thyroid Myopathy—by aligning clinical clues with diagnostic tests (p. 8). Detailed laboratory and imaging results are provided, featuring a positive anti-AChR antibody serology, a decremental response on repetitive nerve stimulation, and a normal brain MRI to confirm a final diagnosis of generalized, non-thymomatous Myasthenia Gravis (pp. 9-10). Additionally, the manual features an evidence-based management plan covering first-line pyridostigmine dosing, immunosuppressive therapy, safety considerations for high-risk medications to avoid, and interactive NGN/ATI-style case questions with complete clinical rationales (pp. 11-12, 14).

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, i-Human Comprehensive Case Study: 55-Year-Old
Patient with Acute Confusion


Class 6550 – Week #8




Part 1: History Taking


Table 1.1 – Demographic & Presenting Problem

Variable Details

Patient Name Robert Coleman (fictional, representative case)

Age 55 years

Gender Male

Ethnicity African American

Chief Complaint (Collateral “He’s confused – doesn’t know where he is, saw him talking to himself,
source – wife) he tried to leave the house at 2 AM.”

Onset Acute – changed from baseline over 24–48 hours

Setting Emergency department (brought by wife)

, Table 1.2 – OPQRST for Acute Confusion (Collateral – Wife)

Question Wife’s Response

“Two days ago he was fine. Yesterday he forgot my name and couldn’t find the
Onset
bathroom.”

Provoking/Palliating Worse at night (sundowning), better when calm/familiar

Quality Disoriented to time/place; seeing “bugs on the wall” (visual hallucinations)

Region/Radiation Whole brain – global confusion

Severity “He’s not himself – I’m scared.” (Moderate–severe impairment)

Timing Acute over 1–2 days; no similar episode before




Table 1.3 – Collateral Past Medical History (PMH)

Condition Details

Type 2 diabetes Diagnosed 10 years ago; metformin 1000 mg BID

Hypertension Diagnosed 8 years ago; lisinopril 20 mg daily

Hyperlipidemia Atorvastatin 20 mg daily

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