Phm 431 Exam ACTUAL QUESTIONS
AND CORRECT ANSWERS
Methylphenidate - correct answer ritalin
Ambien - correct answer no-go pills
Methamphetamine and amphetamine
Da and ne a _______ charged at physiologic ph - correct answer positively
How do enzymes inactivate catecholamines? - correct answer they modify the functional group
Mao
Comt
Amphetamine related compounds have structural differences that make them ______ to mao and comt
- correct answer resistant
_____ is the active ingredient in sudafed and other nasal decongestants - correct
answer pseudoephedrine
Amphetamine is a substrate for _____ but not a substrate for _______ - correct answer vmat
Mao
Amphetamine in vmat causes ______ - correct answer transporter reversal to transport da and
ne out through dat or net into the synaptic cleft
Euphoric effect of amphetamine are mediated by - correct answer mesolimbic dopamine system
Amphetamine causes dopamine release in the _____ - correct answer nucleus accumbens
, ______ studies are used in rats to assess reinforcing properties of amphetamines - correct
answer conditioned place preference protocols
Pet studies in humans use _____ to confirm mechanisms of amphetamine actions - correct
answer c-raclopride
How did amphetamine treatment change the raclopride binding in the na? - correct
answer decreased
Cart - correct answer cocaine and amphetamine related transcript
Mapped to human chromosome 5q13-14 locus
What do cart peptides do? - correct answer contribute to satiety.
inhibit feeding behavior caused by neuropeptide y.
Methamphetamine causes neurotoxicity by - correct answer killing dopamine neurons through
the formation of reactive intermediates (quinones)
Amphetamine induced cardiovascular toxicity - correct answer ne is released and acts of
postsynaptic alpha and beta receptors
Activation of beta receptors - correct answer increase heart rate and excitability of cardiac
muscles
Activation of alpha receptors - correct answer increase vasoconstriction
Maoi - correct answer monoamine oxidase inhibitors
Used to treat depression and social anxiety disorders
Patients taking maoi's require a _____ free diet. Why? - correct answer tyramine
Consumption of tryramine-containing foods can cause a hypertensive crisis (stroke, heart attack,
kidney, and retinal damage)
AND CORRECT ANSWERS
Methylphenidate - correct answer ritalin
Ambien - correct answer no-go pills
Methamphetamine and amphetamine
Da and ne a _______ charged at physiologic ph - correct answer positively
How do enzymes inactivate catecholamines? - correct answer they modify the functional group
Mao
Comt
Amphetamine related compounds have structural differences that make them ______ to mao and comt
- correct answer resistant
_____ is the active ingredient in sudafed and other nasal decongestants - correct
answer pseudoephedrine
Amphetamine is a substrate for _____ but not a substrate for _______ - correct answer vmat
Mao
Amphetamine in vmat causes ______ - correct answer transporter reversal to transport da and
ne out through dat or net into the synaptic cleft
Euphoric effect of amphetamine are mediated by - correct answer mesolimbic dopamine system
Amphetamine causes dopamine release in the _____ - correct answer nucleus accumbens
, ______ studies are used in rats to assess reinforcing properties of amphetamines - correct
answer conditioned place preference protocols
Pet studies in humans use _____ to confirm mechanisms of amphetamine actions - correct
answer c-raclopride
How did amphetamine treatment change the raclopride binding in the na? - correct
answer decreased
Cart - correct answer cocaine and amphetamine related transcript
Mapped to human chromosome 5q13-14 locus
What do cart peptides do? - correct answer contribute to satiety.
inhibit feeding behavior caused by neuropeptide y.
Methamphetamine causes neurotoxicity by - correct answer killing dopamine neurons through
the formation of reactive intermediates (quinones)
Amphetamine induced cardiovascular toxicity - correct answer ne is released and acts of
postsynaptic alpha and beta receptors
Activation of beta receptors - correct answer increase heart rate and excitability of cardiac
muscles
Activation of alpha receptors - correct answer increase vasoconstriction
Maoi - correct answer monoamine oxidase inhibitors
Used to treat depression and social anxiety disorders
Patients taking maoi's require a _____ free diet. Why? - correct answer tyramine
Consumption of tryramine-containing foods can cause a hypertensive crisis (stroke, heart attack,
kidney, and retinal damage)
