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ATI Fundamentals for Nursing Study Guide 2026: 140 NCLEX-RN/PN Questions & Answers with Rationales – Safe Care, Health Promotion, Pharmacology, Psychosocial Integrity, Basic Care

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This comprehensive 91-page study guide contains 140 high-yield ATI-style questions and answers for Nursing Fundamentals. Organized into 9 sections—Safe & Effective Care Environment (25 Qs), Health Promotion & Maintenance (15 Qs), Psychosocial Integrity (10 Qs), Basic Care & Comfort (15 Qs), Pharmacology & Parenteral Therapies (20 Qs), Reduction of Risk Potential (15 Qs), Physiological Adaptation (15 Qs), Nursing Process (10 Qs), and Comprehensive Mixed Review (15 Qs). Each question includes the correct answer and detailed rationale. Topics include infection control, restraints, urinary catheters, enemas, sterile technique, IV therapy, blood transfusion reactions, tracheostomy care, chest tubes, medication administration, pressure injury prevention, advance directives, dementia care, suicide assessment, and more. Perfect for ATI Fundamentals proctored exam prep, NCLEX-RN/PN candidates, and nursing students. Updated to 2026 standards. Graded A+.

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1|Page


# ATI FUNDAMENTALS FOR NURSING STUDY GUIDE
## COMPLETE Q&A BANK | LATEST EDITION | A+
RATED
### FIRST-TIME PASS GUARANTEE | UPDATED FOR
2026



## Table of Contents


| Section | Topic | Questions |
|---------|-------|-----------|
| 1 | Safe & Effective Care Environment (Management of Care, Safety & Infection
Control) | 25 |
| 2 | Health Promotion & Maintenance | 15 |
| 3 | Psychosocial Integrity | 10 |
| 4 | Basic Care & Comfort | 15 |
| 5 | Pharmacology & Parenteral Therapies | 20 |
| 6 | Reduction of Risk Potential | 15 |
| 7 | Physiological Adaptation | 15 |
| 8 | Nursing Process & Critical Thinking | 10 |
| 9 | Comprehensive Mixed Review | 15 |


---

,2|Page


# SECTION 1: SAFE & EFFECTIVE CARE ENVIRONMENT
## (Management of Care, Safety & Infection Control)
### Questions 1–25


---


**1.** A nurse is preparing to administer a blood transfusion to a client. Which of
the following actions is most important to prevent a transfusion reaction?


A) Verify the client's blood type and crossmatch with another nurse
B) Administer the blood at a rate of 10 mL/min for the first 15 minutes
C) Use a 22-gauge intravenous catheter for transfusion
D) Infuse dextrose 5% in water with the blood product


**Answer:** A) Verify the client's blood type and crossmatch with another nurse


**Rationale:** The most important action to prevent a hemolytic transfusion
reaction is verifying the client's identity, blood type, and crossmatch with another
qualified nurse (two-nurse verification). This ensures compatibility and prevents
ABO incompatibility, which is the most dangerous transfusion reaction.


---


**2.** A nurse is caring for a client who has a new order for wrist restraints.
Which of the following actions should the nurse take?

,3|Page


A) Apply the restraints tightly to prevent movement
B) Tie the restraints to the side rail of the bed
C) Remove the restraints every 2 hours to assess skin and provide range of motion
D) Obtain a verbal order from the provider and document within 24 hours


**Answer:** C) Remove the restraints every 2 hours to assess skin and provide
range of motion


**Rationale:** Restraints must be removed at least every 2 hours (more frequently
depending on facility policy) to assess skin integrity, provide range of motion, and
address basic needs. Restraints should not be tied to side rails (risk of injury).


---


**3.** A nurse is preparing to transfer a client from a bed to a stretcher. Which of
the following actions should the nurse take to prevent back injury?


A) Keep feet close together when lifting
B) Use a draw sheet to slide the client, keeping back straight and using leg muscles
C) Lift the client using a twisting motion
D) Have only one staff member perform the transfer


**Answer:** B) Use a draw sheet to slide the client, keeping back straight and
using leg muscles

, 4|Page


**Rationale:** To prevent back injury, the nurse should keep feet shoulder-width
apart, use leg muscles (not back), keep the back straight, and avoid twisting. Using
a draw sheet reduces lifting strain.


---


**4.** A nurse is caring for a client who has a central venous catheter (CVC).
Which of the following actions should the nurse take when changing the dressing?


A) Use sterile gloves for the entire procedure
B) Clean the site with alcohol only
C) Apply a transparent dressing and change it every 7 days
D) Wear clean gloves for removal of old dressing, then sterile gloves for the new
dressing


**Answer:** D) Wear clean gloves for removal of old dressing, then sterile gloves
for the new dressing


**Rationale:** Central line dressing changes require sterile technique. Clean
gloves are used to remove the old dressing. Then sterile gloves are donned for
cleaning the site and applying the new sterile dressing.


---


**5.** A nurse is caring for a client who has a new prescription for an indwelling
urinary catheter. Which of the following actions should the nurse take to prevent
catheter-associated urinary tract infection (CAUTI)?

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