NR507 Week 8 Final Exam – Chamberlain University
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,NR507 Week 8 Final Exam Practice Test Advanced
Pathophysiology - Chamberlain University
This comprehensive practice exam is based on the NR507 Advanced
Pathophysiology final exam blueprint, covering Weeks 5-8 material. Questions are
formatted to reflect the actual exam style with multiple-choice, select-all-that-
apply, and case-based questions.
SECTION 1: Cellular Adaptation & Injury (Questions 1-10)
,Question 1
A client with long-standing hypertension develops an enlarged left ventricle. This
is an example of which cellular adaptation?
A) Hyperplasia
B) Hypertrophy
C) Atrophy
D) Metaplasia
Answer: B
Rationale: Hypertrophy is an increase in cell size leading to organ enlargement.
Cardiac muscle cells cannot divide (hyperplasia), so they enlarge in response to
increased workload from hypertension. This is an adaptive response that can
become maladaptive over time .
Question 2
A client who smokes develops a change in the bronchial epithelium from ciliated
columnar to stratified squamous. This is known as:
A) Dysplasia
B) Hyperplasia
C) Metaplasia
D) Anaplasia
Answer: C
Rationale: Metaplasia is the reversible replacement of one differentiated cell type
with another. This is an adaptive response to chronic irritation (smoking). The new
cell type is better able to survive the irritant but loses its specialized function .
Question 3
Coagulative necrosis is most commonly seen in which organ following ischemic
injury?
, A) Brain
B) Heart
C) Lung
D) Pancreas
Answer: B
Rationale: Coagulative necrosis is characteristic of ischemic injury in solid organs
with high protein content and little digestive enzyme activity, such as the heart
(myocardial infarction), kidney, and liver .
Question 4
Liquefactive necrosis is characteristic of:
A) Myocardial infarction
B) Brain infarction (stroke)
C) Tuberculosis
D) Ischemic injury to the kidney
Answer: B
Rationale: Liquefactive necrosis occurs in the brain due to enzymatic digestion of
necrotic tissue by hydrolytic enzymes, forming a cystic space. This is because
neural tissue has high lipid content and few connective tissue fibers .
Question 5
Apoptosis is best described as:
A) Uncontrolled cell death causing inflammation
B) Programmed cell death (physiologic)
C) Necrosis due to ischemia
D) Cell death due to bacterial toxins
Answer: B
Monitored with ExamSoft Exemplify Complete Exact
Questions with Answer Alternatives High-Quality
Nursing Practice Assessment Resource-compressed
,NR507 Week 8 Final Exam Practice Test Advanced
Pathophysiology - Chamberlain University
This comprehensive practice exam is based on the NR507 Advanced
Pathophysiology final exam blueprint, covering Weeks 5-8 material. Questions are
formatted to reflect the actual exam style with multiple-choice, select-all-that-
apply, and case-based questions.
SECTION 1: Cellular Adaptation & Injury (Questions 1-10)
,Question 1
A client with long-standing hypertension develops an enlarged left ventricle. This
is an example of which cellular adaptation?
A) Hyperplasia
B) Hypertrophy
C) Atrophy
D) Metaplasia
Answer: B
Rationale: Hypertrophy is an increase in cell size leading to organ enlargement.
Cardiac muscle cells cannot divide (hyperplasia), so they enlarge in response to
increased workload from hypertension. This is an adaptive response that can
become maladaptive over time .
Question 2
A client who smokes develops a change in the bronchial epithelium from ciliated
columnar to stratified squamous. This is known as:
A) Dysplasia
B) Hyperplasia
C) Metaplasia
D) Anaplasia
Answer: C
Rationale: Metaplasia is the reversible replacement of one differentiated cell type
with another. This is an adaptive response to chronic irritation (smoking). The new
cell type is better able to survive the irritant but loses its specialized function .
Question 3
Coagulative necrosis is most commonly seen in which organ following ischemic
injury?
, A) Brain
B) Heart
C) Lung
D) Pancreas
Answer: B
Rationale: Coagulative necrosis is characteristic of ischemic injury in solid organs
with high protein content and little digestive enzyme activity, such as the heart
(myocardial infarction), kidney, and liver .
Question 4
Liquefactive necrosis is characteristic of:
A) Myocardial infarction
B) Brain infarction (stroke)
C) Tuberculosis
D) Ischemic injury to the kidney
Answer: B
Rationale: Liquefactive necrosis occurs in the brain due to enzymatic digestion of
necrotic tissue by hydrolytic enzymes, forming a cystic space. This is because
neural tissue has high lipid content and few connective tissue fibers .
Question 5
Apoptosis is best described as:
A) Uncontrolled cell death causing inflammation
B) Programmed cell death (physiologic)
C) Necrosis due to ischemia
D) Cell death due to bacterial toxins
Answer: B
