Antimicrobial recall quiz The University of Texas Arlington-NURS 5334

Penicillinase-resistant penicillins Oxacillin, nafcillin, dicloxacillin broad spectrum penicillins - ampicillin and amoxicillin - good oral absorption (amoxicillin = excellent) - broad spectrum (improved against gram negative organisms - , salmonella, shingella, H. Influenza, H pylori, proteus) How do penicillins and cephalosporins work? By weakening the cell wall and promoting lysis and death Bactericidal drugs are Directly lethal to bacteria at achievable concentrations Why are narrow spectrum drugs preferred over broad spectrum antibiotics? Broad spectrum antibiotics do the most to facilitate emergence of resistance How does bacterial resistance develop with penicillins? -production of penicillin binding proteins that have low affinity for penicillins -inability of penicillins to reach their target -inactivation of penicillins by bacterial enzymes