HEMATOLOGY COMPREHENSIVE BLOOD
DISORDERS REVIEW SHEET FULL
SOLUTIONS
●● 3) The majority of the iron in an adult is found as a constituent of:
a. hemoglobin
b. hemosiderin
c. myoglobin
d. transferrin
Answer: a (2/3 iron in body bound to Hgb.)
●● 4) The main function of the hexose monophosphate shunt in the
erythrocyte is to:
a. regulate the level of 2,3-DPG
b. provide reduced glutathione to prevent oxidation of hemoglobin
c. prevent the reduction of heme iron
d. provide energy for membrane maintenance
Answer: b (Maintains in Fe++ form by way of reduced glutathione.)
●● 10) In order for hemoglobin to combine reversibly with oxygen, the
iron must be:
a. complexed with haptoglobin
,b. freely circulating in the cytoplasm
c. attached to transferrin
d. in the ferrous state
Answer: d (Functional form of Fe [reduced].)
●● 11) In which of the following disease states are teardrop cells and
abnormal platelets most characteristically seen?
a. hemolytic anemia
b. multiple myeloma
c. G-6-PD deficiency
d. myeloid metaplasia
Answer: d (RBC morphology; disease state identification.)
●● 13) In the normal adult, the spleen acts as a site for:
a. storage of RBCs
b. production of RBCs
c. synthesis of erythropoietin
d. removal of imperfect and aging cells
Answer: d (Major site of destruction of senescent red blood cells.)
●● 14) After the removal of RBCs from the circulation hemoglobin is
broken down into:
a. iron, prophyrin, amino acids
,b. iron, protoporphyrin, globin
c. heme, protoporphyrin, amino acids
d. heme, hemosiderin, globin
Answer: b (Normal degradation products of red blood cells.)
●● 15) Heinz bodies are:
a. readily identified with polychrome stains
b. rarely found in glucose-6-phosphate dehydrogenase deficient
erythrocytes
c. closely associated with spherocytes
d. denatured hemoglobin inclusion that are readily removed by the
spleen
Answer: d (Formed with oxidization of Fe and formation of
methemoglobin.)
●● 17) Cells for the transport of O2 and CO2 are:
a. erythrocytes
b. granulocytes
c. lymphocytes
d. thrombocytes
Answer: a (Primary functions of red blood cells.)
●● 18) Erythropoietin acts as:
, a. shorten the replication time of the granulocytes
b. stimulate RNA synthesis of erythroid cells
c. increase colony-stimulating factors produced by the B-lymphs
d. decrease the release of marrow reticulocytes
Answer: b (Erythropoietin action.)
●● 19) What cell shape is most commonly associated with an increased
MCHC?
a. teardrop cells
b. target cells
c. spherocytes
d. sickle cells
Answer: c (May be referred to as hyperchromic because of decreased
MCHC.)
●● 27) Which of the following characteristics are common to hereditary
spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and
paroxysmal nocturnal hemoglobinuria?
a. autosomal dominant inheritance
b. red cell membrane defect
c. positive DAT
d. measured platelet count
Answer: b (RBC membrane defects are common to PNH, HS, and HE.)
DISORDERS REVIEW SHEET FULL
SOLUTIONS
●● 3) The majority of the iron in an adult is found as a constituent of:
a. hemoglobin
b. hemosiderin
c. myoglobin
d. transferrin
Answer: a (2/3 iron in body bound to Hgb.)
●● 4) The main function of the hexose monophosphate shunt in the
erythrocyte is to:
a. regulate the level of 2,3-DPG
b. provide reduced glutathione to prevent oxidation of hemoglobin
c. prevent the reduction of heme iron
d. provide energy for membrane maintenance
Answer: b (Maintains in Fe++ form by way of reduced glutathione.)
●● 10) In order for hemoglobin to combine reversibly with oxygen, the
iron must be:
a. complexed with haptoglobin
,b. freely circulating in the cytoplasm
c. attached to transferrin
d. in the ferrous state
Answer: d (Functional form of Fe [reduced].)
●● 11) In which of the following disease states are teardrop cells and
abnormal platelets most characteristically seen?
a. hemolytic anemia
b. multiple myeloma
c. G-6-PD deficiency
d. myeloid metaplasia
Answer: d (RBC morphology; disease state identification.)
●● 13) In the normal adult, the spleen acts as a site for:
a. storage of RBCs
b. production of RBCs
c. synthesis of erythropoietin
d. removal of imperfect and aging cells
Answer: d (Major site of destruction of senescent red blood cells.)
●● 14) After the removal of RBCs from the circulation hemoglobin is
broken down into:
a. iron, prophyrin, amino acids
,b. iron, protoporphyrin, globin
c. heme, protoporphyrin, amino acids
d. heme, hemosiderin, globin
Answer: b (Normal degradation products of red blood cells.)
●● 15) Heinz bodies are:
a. readily identified with polychrome stains
b. rarely found in glucose-6-phosphate dehydrogenase deficient
erythrocytes
c. closely associated with spherocytes
d. denatured hemoglobin inclusion that are readily removed by the
spleen
Answer: d (Formed with oxidization of Fe and formation of
methemoglobin.)
●● 17) Cells for the transport of O2 and CO2 are:
a. erythrocytes
b. granulocytes
c. lymphocytes
d. thrombocytes
Answer: a (Primary functions of red blood cells.)
●● 18) Erythropoietin acts as:
, a. shorten the replication time of the granulocytes
b. stimulate RNA synthesis of erythroid cells
c. increase colony-stimulating factors produced by the B-lymphs
d. decrease the release of marrow reticulocytes
Answer: b (Erythropoietin action.)
●● 19) What cell shape is most commonly associated with an increased
MCHC?
a. teardrop cells
b. target cells
c. spherocytes
d. sickle cells
Answer: c (May be referred to as hyperchromic because of decreased
MCHC.)
●● 27) Which of the following characteristics are common to hereditary
spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and
paroxysmal nocturnal hemoglobinuria?
a. autosomal dominant inheritance
b. red cell membrane defect
c. positive DAT
d. measured platelet count
Answer: b (RBC membrane defects are common to PNH, HS, and HE.)
