WITH 100% CORRECT ANSWERS AND DETAILED
RATIONALES
1. A 58-year-old with COPD exacerbation is on BiPAP (IPAP 14, EPAP 6, FIO2 0.4).
ABG: pH 7.31, PaCO2 68, PaO2 68, HCO3 28. Next step?
A. Increase IPAP to 18
B. Intubate and ventilate
C. Decrease EPAP to 4
D. Change to CPAP at 10
Correct: A – Increasing IPAP improves alveolar ventilation, lowering PaCO2. EPAP 6
is adequate for oxygenation. Intubation not needed if noninvasive ventilation can
be optimized. CPAP won’t help hypercapnia.
2. Which ventilator mode is best for a patient with severe ARDS and plateau
pressure 32 cm H2O on VCV?
A. Pressure control with inverse ratio (PC-IRV)
B. High-frequency oscillatory ventilation (HFOV)
C. Airway pressure release ventilation (APRV)
D. Pressure support ventilation (PSV)
Correct: C – APRV allows spontaneous breathing while maintaining high mean
airway pressure, potentially reducing barotrauma. PC-IRV may increase mean
pressure but sedation needs are high. HFOV is second-line. PSV inadequate in
severe ARDS.
3. A 45-year-old with traumatic brain injury has ICP 22 mm Hg, CPP 58 mm Hg.
PaCO2 is 45 mm Hg. Best intervention?
,A. Hyperventilate to PaCO2 30 mm Hg
B. Mannitol 1 g/kg IV
C. Increase PEEP to 15 cm H2O
D. Elevate HOB to 90 degrees
Correct: B – Mannitol reduces ICP rapidly. Hyperventilation is only for herniation,
not routine. High PEEP may reduce venous return and ICP if autoregulation
impaired. HOB 30° is standard; 90° risks hypotension.
4. Which finding indicates weaning failure in a patient on pressure support of 8 cm
H2O?
A. RSBI = 55 breaths/min/L
B. P0.1 = 6 cm H2O
C. MIP = −30 cm H2O
D. VT = 6 mL/kg
Correct: B – P0.1 (airway occlusion pressure at 100 ms) > 4–6 cm H2O suggests
high respiratory drive and impending failure. RSBI < 105 suggests success. MIP −30
adequate. VT 6 mL/kg is acceptable.
5. A patient with pulmonary embolism develops hypotension. TTE shows right
ventricular dilation. What is the best initial therapy?
A. Alteplase 100 mg IV
B. Unfractionated heparin bolus
C. Norepinephrine infusion
D. Dobutamine infusion
Correct: C – Norepinephrine restores perfusion to RV and systemic circulation.
Thrombolytics indicated if hemodynamic collapse, but not first line before
stabilization. Heparin alone won’t reverse shock. Dobutamine can worsen
hypotension if RV ischemia.
,6. While suctioning an intubated patient, heart rate drops from 110 to 48 bpm.
Action?
A. Continue suctioning to clear secretions
B. Administer atropine 0.5 mg IV
C. Stop suctioning and give 100% O2
D. Increase PEEP to recruit atelectasis
Correct: C – Bradycardia from vagal stimulation requires immediate cessation of
suction and hyperoxygenation. Atropine is second step if persists. Continuing
worsens hypoxia/bradycardia. PEEP not relevant.
7. Which ABG indicates optimal ventilation for a status asthmaticus patient on
mechanical ventilation?
A. pH 7.28, PaCO2 55, PaO2 90
B. pH 7.38, PaCO2 40, PaO2 80
C. pH 7.30, PaCO2 65, PaO2 70
D. pH 7.48, PaCO2 32, PaO2 95
Correct: A – Permissive hypercapnia (pH >7.25, PaCO2 up to 60-70) is target to
avoid dynamic hyperinflation. Normal PaCO2 may require high rate/volume,
risking barotrauma. Respiratory acidosis well tolerated.
8. A 70-kg patient with ARDS: VCV, VT 420 mL, Pplat 30, PEEP 14, FIO2 0.8. PaO2
65 mm Hg. Next?
A. Increase VT to 500 mL
B. Increase PEEP to 18
C. Increase FIO2 to 1.0
D. Prone positioning
Correct: D – Prone positioning improves oxygenation in severe ARDS (PaO2/FIO2
<150). PEEP 14 already high; increasing may not help and can drop BP. Increasing
VT worsens lung injury. FIO2 1.0 toxicity.
, 9. A patient with septic shock on norepinephrine 0.3 mcg/kg/min has MAP 62,
CVP 18, ScvO2 65%. Next?
A. Increase norepinephrine
B. Give 500 mL crystalloid
C. Start dobutamine
D. Transfuse PRBCs
Correct: C – ScvO2 <70% despite adequate MAP and CVP (fluid replete) indicates
need for inotropy (dobutamine) to increase O2 delivery. More fluids with CVP 18
risks edema. Transfusion if Hb <7.
10. Which statement about APRV is true?
A. Spontaneous breaths are not allowed in APRV
B. T-high is set longer than T-low
C. APRV requires patient paralysis
D. Release volume equals set tidal volume
Correct: B – APRV uses long T-high (4-6 sec) and short T-low (0.5-0.8 sec) to
maintain mean airway pressure. Spontaneous breaths encouraged. Paralysis not
required. Release volume varies with compliance.
11. A 62-year-old post-op day 2 develops sudden dyspnea, hypotension, and JVD.
What is the priority?
A. STAT chest X-ray
B. ECG for S1Q3T3
C. Bedside echocardiogram
D. Immediate heparin bolus
Correct: C – Suspected massive PE causing obstructive shock; bedside echo (or
TEE) quickly confirms RV strain/dilation faster than CXR or ECG. Heparin before
diagnosis if high suspicion, but echo is diagnostic. S1Q3T3 is late.