GMS 6552 CORE 2026 MAIN QUESTIONS AND ANSWERS SURE A.pdf

GMS 6552 CORE 2026 MAIN QUESTIONS AND ANSWERS
SURE A+
✔✔What enzyme reverses the effects of PI3K?

Ras
AKT
P85
GEF
PTEN - ✔✔PTEN

✔✔The substrate of PI3k, PIP is what type of molecule?

Carbohydrate
Lipid
Protein
Nucleic acid
Inorganic - ✔✔Lipid

✔✔Which enzyme is responsible for inactivating Ras?

AKT
P85
GAP
PTEN - ✔✔GAP

✔✔Which is the proper order of activation in the MAPK signaling cascade?

ERK -> MEK -> MEKK

MEKK -> MEK -> ERK

ERK -> MEKK -> MEK

MEKK -> ERK -> MEK

MEK -> MEKK -> ERK - ✔✔MEKK -> MEK -> ERK

✔✔Many phospholipase C enzymes contain pleckstrin homology domains. What is the
function of these domains?

Bind DNA
Phosphorylate proteins
Phosphatase proteins
Bind proteins

, Bind phosphotidylinositol - ✔✔Bind phosphotidylinositol

✔✔PLC exerts some of its effects through the modulation of which physiological ion?

Sodium
Potassium
Calcium
Chloride - ✔✔Calcium

✔✔Toll-like receptors primarily activate which NF-κB signaling pathway?

Canonical
Non-canonical - ✔✔Canonical

✔✔Based on the effects of Nf-κB signaling, would cancer cells be expected to increase
or decrease its activity for their own benefit?

Increase
Decrease - ✔✔Increase

✔✔Which statement best describes the role of the MyD88 protein in NF-κB signaling?

It phosphorylates NF-κB

It directly degrades of IκB

It prevents the premature activation of NF-κB

It acts as a scaffold to recruit the IKK complex

It acts as a transcription factor in the nucleus - ✔✔It acts as a scaffold to recruit the IKK
complex

✔✔Which statement best describes the role of the IκB protein in NF-κB signaling?

It phosphorylates NF-κB

It directly degrades of IκB

It prevents the premature activation of NF-κB

It acts as a scaffold to recruit the IKK complex

It acts as a transcription factor in the nucleus - ✔✔It prevents the premature activation
of NF-κB