GMS 6552 EXAMINATION LATEST UPDATED QUESTIONS
AND ANSWERS SURE A+
✔✔PLC exerts some of its effects through the modulation of which physiological ion?
Sodium
Potassium
Calcium
Chloride - ✔✔Calcium
✔✔Toll-like receptors primarily activate which NF-κB signaling pathway?
Canonical
Non-canonical - ✔✔Canonical
✔✔Based on the effects of Nf-κB signaling, would cancer cells be expected to increase
or decrease its activity for their own benefit?
Increase
Decrease - ✔✔Increase
✔✔Which statement best describes the role of the MyD88 protein in NF-κB signaling?
It phosphorylates NF-κB
It directly degrades of IκB
It prevents the premature activation of NF-κB
It acts as a scaffold to recruit the IKK complex
It acts as a transcription factor in the nucleus - ✔✔It acts as a scaffold to recruit the IKK
complex
✔✔Which statement best describes the role of the IκB protein in NF-κB signaling?
It phosphorylates NF-κB
It directly degrades of IκB
It prevents the premature activation of NF-κB
It acts as a scaffold to recruit the IKK complex
, It acts as a transcription factor in the nucleus - ✔✔It prevents the premature activation
of NF-κB
✔✔Which statement best describes the role of the p50 protein in NF-κB signaling?
It phosphorylates NF-κB
It directly degrades of IκB
It prevents the premature activation of NF-κB
It acts as a scaffold to recruit the IKK complex
It acts as a transcription factor in the nucleus - ✔✔It acts as a transcription factor in the
nucleus
✔✔Which statement best describes a role of the IKK protein in NF-κB signaling?
It phosphorylates NF-κB
It directly degrades of IκB
It prevents the premature activation of NF-κB
It acts as a scaffold to recruit the IKK complex
It acts as a transcription factor in the nucleus - ✔✔It phosphorylates NF-κB
✔✔How is the activity of the IKK complex modulated in order to determine whether the
complex feeds into the canonical or non-canonical signaling pathway?
If the complex includes NEMO it feeds into the canonical pathway. If the complex
includes DORY, it feeds into the non-canonical pathway.
If the complex is cytosolic, it feeds into the canonical pathway. If the complex is in the
nucleus, it feeds into the non-canonical pathway.
If the complex includes phosphorylated IKKβ, it feeds into the canonical pathway. If the
complex includes phosphorylated IKKα, it feeds into the non-canonical pathway.
If the complex is completely degraded by the proteasome, it feeds into the canonical
pathway. If the complex is partially degraded by the proteasome, it feeds into the non-
canonical pathway. - ✔✔If the complex includes phosphorylated IKKβ, it feeds into the
canonical pathway. If the complex includes phosphorylated IKKα, it feeds into the non-
canonical pathway.
AND ANSWERS SURE A+
✔✔PLC exerts some of its effects through the modulation of which physiological ion?
Sodium
Potassium
Calcium
Chloride - ✔✔Calcium
✔✔Toll-like receptors primarily activate which NF-κB signaling pathway?
Canonical
Non-canonical - ✔✔Canonical
✔✔Based on the effects of Nf-κB signaling, would cancer cells be expected to increase
or decrease its activity for their own benefit?
Increase
Decrease - ✔✔Increase
✔✔Which statement best describes the role of the MyD88 protein in NF-κB signaling?
It phosphorylates NF-κB
It directly degrades of IκB
It prevents the premature activation of NF-κB
It acts as a scaffold to recruit the IKK complex
It acts as a transcription factor in the nucleus - ✔✔It acts as a scaffold to recruit the IKK
complex
✔✔Which statement best describes the role of the IκB protein in NF-κB signaling?
It phosphorylates NF-κB
It directly degrades of IκB
It prevents the premature activation of NF-κB
It acts as a scaffold to recruit the IKK complex
, It acts as a transcription factor in the nucleus - ✔✔It prevents the premature activation
of NF-κB
✔✔Which statement best describes the role of the p50 protein in NF-κB signaling?
It phosphorylates NF-κB
It directly degrades of IκB
It prevents the premature activation of NF-κB
It acts as a scaffold to recruit the IKK complex
It acts as a transcription factor in the nucleus - ✔✔It acts as a transcription factor in the
nucleus
✔✔Which statement best describes a role of the IKK protein in NF-κB signaling?
It phosphorylates NF-κB
It directly degrades of IκB
It prevents the premature activation of NF-κB
It acts as a scaffold to recruit the IKK complex
It acts as a transcription factor in the nucleus - ✔✔It phosphorylates NF-κB
✔✔How is the activity of the IKK complex modulated in order to determine whether the
complex feeds into the canonical or non-canonical signaling pathway?
If the complex includes NEMO it feeds into the canonical pathway. If the complex
includes DORY, it feeds into the non-canonical pathway.
If the complex is cytosolic, it feeds into the canonical pathway. If the complex is in the
nucleus, it feeds into the non-canonical pathway.
If the complex includes phosphorylated IKKβ, it feeds into the canonical pathway. If the
complex includes phosphorylated IKKα, it feeds into the non-canonical pathway.
If the complex is completely degraded by the proteasome, it feeds into the canonical
pathway. If the complex is partially degraded by the proteasome, it feeds into the non-
canonical pathway. - ✔✔If the complex includes phosphorylated IKKβ, it feeds into the
canonical pathway. If the complex includes phosphorylated IKKα, it feeds into the non-
canonical pathway.
