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COMSAE Phase 1 Form 111 EXAM QUESTIONS AND CORRECT
VERIFIED SOLUTIONS LATEST UPDATE THIS YEAR – JUST
RELEASED
COMSAE Phase 1 Form 111 Practice Exam
Summarized Exam Coverage
The COMSAE (Comprehensive Osteopathic Medical Self-Assessment Examination) Phase 1 Form
111 is designed to assess readiness for COMLEX-USA Level 1, covering foundational biomedical
sciences with emphasis on osteopathic principles and clinical problem-solving. The exam
consists of 176 questions across four sections of 44 questions each, in a single-best-answer,
multiple-choice format featuring clinical vignettes and images.
Key Exam Domains:
Domain Focus Areas
Chapman reflexes (anterior/posterior), sacral diagnosis (torsions, dural tube tension
Osteopathic Principles mechanics), viscerosomatic reflexes, counterstrain tender points (anterior/posterio
& Practice cranial motion, autonomic nervous system pathways, facilitated segmental
examination
Immunology, microbiology, biochemistry (metabolic pathways, vitamin deficiencies
General Principles &
genetics, pharmacology (mechanisms, adverse effects, drug interactions), patholog
Foundational Science
(neoplasia, inflammation, cell injury)
Hematology & Anemias (iron deficiency, B12 deficiency, hemolytic), leukemias/lymphomas,
Oncology coagulation disorders, transfusion medicine, clotting factor deficiencies
Ischemic heart disease (STEMI/NSTEMI), heart failure, valvular disorders, arrhythm
Cardiovascular System (Long QT, WPW, atrial fibrillation), hypertension, cardiomyopathies, cardiac
auscultation findings (S3, S4, murmurs)
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Domain Focus Areas
Obstructive lung disease (COPD, asthma), restrictive lung disease (IPF, sarcoidosis),
Pulmonary System pneumonia, tuberculosis, pulmonary embolism, pneumothorax, lung cancer,
oxygenation/ventilation
Acute kidney injury (prerenal, intrarenal, postrenal), chronic kidney disease,
Renal & Urinary
glomerulonephritis (PSGN, IgA nephropathy), nephrotic syndrome, renal tubular
System
acidosis, fluid/electrolyte disorders, acid-base balance
Inflammatory bowel disease (Crohn's vs. UC), pancreatitis (gallstones, alcohol),
Gastrointestinal
hepatitis (viral, autoimmune), cirrhosis, biliary disease, peptic ulcer disease, GI
System
bleeding
Thyroid disorders (hypo/hyper), adrenal disorders (Cushing's, Addison's), diabetes
Endocrine System mellitus (Type 1 vs. 2, complications), parathyroid disorders (hyperparathyroidism),
pituitary disorders
Stroke (ischemic vs. hemorrhagic, artery localization), seizures, meningitis, multiple
Neurology sclerosis, Parkinson's disease, Alzheimer's disease, brain tumors (cerebellopontine
angle), neuromuscular junction disorders
Viral (EBV, CMV, HIV), bacterial (pneumonia, UTI, meningitis, STIs), fungal (PJP, cand
Infectious Disease
histoplasmosis), parasitic (giardia, toxoplasma, balantidium), antimicrobial therapy
Musculoskeletal & Osteoarthritis vs. rheumatoid arthritis, gout, pseudogout, systemic lupus
Rheumatology erythematosus, scleroderma, ankylosing spondylitis, osteoporosis, Paget's disease
Reproductive & Hormonal regulation, STIs, pregnancy complications, teratogens, contraception,
Pregnancy infertility, testicular tumors, ovarian tumors
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Domain Focus Areas
Depression, bipolar disorder, anxiety disorders, schizophrenia, substance use disord
Psychiatry
eating disorders, suicide risk assessment
Special Populations Pediatrics (croup, epiglottitis, congenital disorders), geriatrics, pregnancy
Randomized Practice Questions with Answers & Rationales
Question 1
A 24-year-old male presents with fever, sore throat, and fatigue. Exam shows posterior cervical
lymphadenopathy and splenomegaly. Which organism is most likely responsible?
A) Streptococcus pyogenes
B) Epstein-Barr virus
C) Cytomegalovirus
D) Toxoplasma gondii
Answer: B
Rationale: This presentation is classic for infectious mononucleosis caused by Epstein-Barr virus
(EBV), characterized by fever, pharyngitis, posterior cervical lymphadenopathy, and
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splenomegaly. The Monospot test (heterophile antibody) would be positive in EBV infection.
CMV can cause a similar syndrome but typically lacks severe pharyngitis.
Question 2
Which cranial nerve is responsible for facial expression?
A) CN V (Trigeminal)
B) CN VII (Facial)
C) CN IX (Glossopharyngeal)
D) CN X (Vagus)
Answer: B
Rationale: The facial nerve (CN VII) innervates the muscles of facial expression. CN V is
responsible for mastication and facial sensation; CN IX supplies the stylopharyngeus and taste to
the posterior tongue; CN X supplies palatal and laryngeal muscles.
Question 3
A patient has right-sided weakness and aphasia. Which cerebral artery is most likely affected?
COMSAE Phase 1 Form 111 EXAM QUESTIONS AND CORRECT
VERIFIED SOLUTIONS LATEST UPDATE THIS YEAR – JUST
RELEASED
COMSAE Phase 1 Form 111 Practice Exam
Summarized Exam Coverage
The COMSAE (Comprehensive Osteopathic Medical Self-Assessment Examination) Phase 1 Form
111 is designed to assess readiness for COMLEX-USA Level 1, covering foundational biomedical
sciences with emphasis on osteopathic principles and clinical problem-solving. The exam
consists of 176 questions across four sections of 44 questions each, in a single-best-answer,
multiple-choice format featuring clinical vignettes and images.
Key Exam Domains:
Domain Focus Areas
Chapman reflexes (anterior/posterior), sacral diagnosis (torsions, dural tube tension
Osteopathic Principles mechanics), viscerosomatic reflexes, counterstrain tender points (anterior/posterio
& Practice cranial motion, autonomic nervous system pathways, facilitated segmental
examination
Immunology, microbiology, biochemistry (metabolic pathways, vitamin deficiencies
General Principles &
genetics, pharmacology (mechanisms, adverse effects, drug interactions), patholog
Foundational Science
(neoplasia, inflammation, cell injury)
Hematology & Anemias (iron deficiency, B12 deficiency, hemolytic), leukemias/lymphomas,
Oncology coagulation disorders, transfusion medicine, clotting factor deficiencies
Ischemic heart disease (STEMI/NSTEMI), heart failure, valvular disorders, arrhythm
Cardiovascular System (Long QT, WPW, atrial fibrillation), hypertension, cardiomyopathies, cardiac
auscultation findings (S3, S4, murmurs)
, Page 2 of 218
Domain Focus Areas
Obstructive lung disease (COPD, asthma), restrictive lung disease (IPF, sarcoidosis),
Pulmonary System pneumonia, tuberculosis, pulmonary embolism, pneumothorax, lung cancer,
oxygenation/ventilation
Acute kidney injury (prerenal, intrarenal, postrenal), chronic kidney disease,
Renal & Urinary
glomerulonephritis (PSGN, IgA nephropathy), nephrotic syndrome, renal tubular
System
acidosis, fluid/electrolyte disorders, acid-base balance
Inflammatory bowel disease (Crohn's vs. UC), pancreatitis (gallstones, alcohol),
Gastrointestinal
hepatitis (viral, autoimmune), cirrhosis, biliary disease, peptic ulcer disease, GI
System
bleeding
Thyroid disorders (hypo/hyper), adrenal disorders (Cushing's, Addison's), diabetes
Endocrine System mellitus (Type 1 vs. 2, complications), parathyroid disorders (hyperparathyroidism),
pituitary disorders
Stroke (ischemic vs. hemorrhagic, artery localization), seizures, meningitis, multiple
Neurology sclerosis, Parkinson's disease, Alzheimer's disease, brain tumors (cerebellopontine
angle), neuromuscular junction disorders
Viral (EBV, CMV, HIV), bacterial (pneumonia, UTI, meningitis, STIs), fungal (PJP, cand
Infectious Disease
histoplasmosis), parasitic (giardia, toxoplasma, balantidium), antimicrobial therapy
Musculoskeletal & Osteoarthritis vs. rheumatoid arthritis, gout, pseudogout, systemic lupus
Rheumatology erythematosus, scleroderma, ankylosing spondylitis, osteoporosis, Paget's disease
Reproductive & Hormonal regulation, STIs, pregnancy complications, teratogens, contraception,
Pregnancy infertility, testicular tumors, ovarian tumors
, Page 3 of 218
Domain Focus Areas
Depression, bipolar disorder, anxiety disorders, schizophrenia, substance use disord
Psychiatry
eating disorders, suicide risk assessment
Special Populations Pediatrics (croup, epiglottitis, congenital disorders), geriatrics, pregnancy
Randomized Practice Questions with Answers & Rationales
Question 1
A 24-year-old male presents with fever, sore throat, and fatigue. Exam shows posterior cervical
lymphadenopathy and splenomegaly. Which organism is most likely responsible?
A) Streptococcus pyogenes
B) Epstein-Barr virus
C) Cytomegalovirus
D) Toxoplasma gondii
Answer: B
Rationale: This presentation is classic for infectious mononucleosis caused by Epstein-Barr virus
(EBV), characterized by fever, pharyngitis, posterior cervical lymphadenopathy, and
, Page 4 of 218
splenomegaly. The Monospot test (heterophile antibody) would be positive in EBV infection.
CMV can cause a similar syndrome but typically lacks severe pharyngitis.
Question 2
Which cranial nerve is responsible for facial expression?
A) CN V (Trigeminal)
B) CN VII (Facial)
C) CN IX (Glossopharyngeal)
D) CN X (Vagus)
Answer: B
Rationale: The facial nerve (CN VII) innervates the muscles of facial expression. CN V is
responsible for mastication and facial sensation; CN IX supplies the stylopharyngeus and taste to
the posterior tongue; CN X supplies palatal and laryngeal muscles.
Question 3
A patient has right-sided weakness and aphasia. Which cerebral artery is most likely affected?
