CPIA CORE EXAMS ACTUAL SET QUESTIONS AND
ANSWERS GRADED A+
✔✔Which of the following is not an example of reduction?
A. The use of a new anesthetic that provides better induction and a shorter recovery
period.
B. The shared use of tissues by more than one investigator to minimize animal use.
C. The use of improved assays that provide better data precision so that fewer animals
are needed per group.
D. The use of common control groups during simultaneous experiments to limit the
number of control animals needed. - ✔✔A. The use of a new anesthetic that provides
better induction and a shorter recovery period.
✔✔Which of the following is not an example of refinement?
A. The use of newer surgical techniques that result in less tissue trauma.
B. The use of a new analgesic that provides better postoperative pain relief.
C. The use of computer modeling software to substitute for animal experiments.
D. The use of a new bleeding technique that causes less pain and distress. - ✔✔C. The
use of computer modeling software to substitute for animal experiments.
✔✔What is required, of the IACUC, by the USDA AWA Regulations regarding
alternatives?
A. Ensure that the limit on animal use assigned to the institution by the USDA is not
exceeded more than once every three years.
B. Reduce animal usage by at least 10% per year over a five-year period.
C. Reduce animal usage by at least 25% over a five-year period.
D. Ensure that the principal investigator has considered alternatives to painful or
distressing procedures, and review a written assurance that alternatives are not
available. - ✔✔D. Ensure that the principal investigator has considered alternatives to
painful or distressing procedures, and review a written assurance that alternatives are
not available.
✔✔What is the basis for the pain/distress classification system used by most
institutions?
A. AAALAC pain/distress categories.
B. PHS pain/distress categories.
C. USDA pain/distress categories.
D. Guide pain/distress categories. - ✔✔C. USDA pain/distress categories.
✔✔Which of the following activities would disqualify an animal from USDA category B?
A. Blood collection.
B. Being placed into new caging.
C. Breeding.
D. Being observed during quarantine. - ✔✔A. Blood collection.
,✔✔Which of the following activities would disqualify an animal from USDA category D?
A. Retroorbital blood collection from a mouse performed under anesthesia.
B. Collecting tail snips from adult rodents for genotyping under local or general
anesthesia.
C. Surgery performed under anesthesia.
D. Studies in which animals are allowed to die without pain relief. - ✔✔D. Studies in
which animals are allowed to die without pain relief.
✔✔An investigator wishes to use animals in an experiment that involves category B, C,
and D activities performed on the same animal. How should the animal be categorized?
A. Categories B, C, and D.
B. Category B.
C. Category C.
D. Category D. - ✔✔D. Category D.
✔✔Which of the following activities would place an animal in category E?
A. Lethal dose experiments in which animals are allowed to die without intervention.
B. Observation studies of normal primate behavior.
C. Blood collection from a superficial vessel of a dog.
D. Major surgery in which anesthetics and postoperative analgesics are administered. -
✔✔A. Lethal dose experiments in which animals are allowed to die without intervention.
✔✔All personnel performing animal procedures must be properly trained to do so
when?
A. By the end of the experiments.
B. Before any procedures are performed.
C. Before any procedures are performed unless they have doctoral level or medical
degrees.
D. Before any procedures are performed unless they receive a waiver from their
supervisor. - ✔✔B. Before any procedures are performed.
✔✔Which statement about the Occupational Health and Safety Program is false?
A. You should enroll in the local Occupational Health and Safety Program before you
begin your work with laboratory animals.
B. Typical services include rabies immunizations, TB testing, and tetanus
immunizations.
C. You may not decline medical treatments provided as part of the Occupational Health
and Safety Program.
D. Each institution must have an Occupational Health and Safety Program for personnel
who have significant contact with laboratory animals. - ✔✔C. You may not decline
medical treatments provided as part of the Occupational Health and Safety Program.
✔✔Which of the following is false concerning prolonged restraint of animals?
A. The restraint method used should be the least restrictive possible that will allow
achievement of experimental objectives.
,B. It can be justified as a convenience for the research staff.
C. The period of restraint should be the minimum required to achieve experimental
objectives.
D. It should not be considered a normal method of housing. - ✔✔B. It can be justified as
a convenience for the research staff.
✔✔Which of the following is true of the dog exercise program mandated by the USDA
Animal Welfare Act regulations?
A. Dogs must be provided additional exercise regardless of the floor area of the cage.
B. The IACUC can exempt an animal for scientific reasons.
C. The veterinarian cannot exempt an animal, even for medical reasons.
D. The veterinarian can exempt an animal for scientific reasons. - ✔✔B. The IACUC can
exempt an animal for scientific
✔✔Great Southern Agricultural and Technical University has an Animal Welfare
Assurance Statement on file with OLAW that covers all PHS funded projects. The
University's policy states that all use of live vertebrate animals for teaching and research
requires IACUC review and approval. A faculty member contacts the IACUC Chair to
report that he demonstrated a blood sampling procedure on a live chicken for a teaching
lab, but it was not the blood sampling method described in the IACUC approved
protocol for the lab. The IACUC must report this noncompliance to:
1) OLAW
2) USDA
3) The University's IO
4) All of the above - ✔✔3) The University's IO
✔✔The institution's PHS Assurance applies to PHS-funded projects only. An
investigator has two IACUC protocols using mice. Protocol A (NIH funded) stipulates
that animals will be killed by barbiturate overdose while decapitation would be the
method used in Protocol B (private foundation funds). The investigator informs the
IACUC Office that his staff mistakenly euthanized a few animals assigned to Protocol B
with barbiturate overdose. How should the IACUC respond?
a) Suspend the investigator.
b) Report to US Department of Agriculture.
c) Report to Office of Laboratory Animal Welfare.
d) Retrain the investigator and staff. - ✔✔a) you could suspend, but it's not required,
and would probably make people mad at the IACUC.
b) reporting noncompliance to the USDA is not required.
c) this institution's Assurance applies to PHS funded activities only therefore reporting
noncompliance on a project not funded by the PHS is not required.
d) probably the best practice to prevent future noncompliance.
Source: Certified Professional IACUC Administrator (CPIA) Study Group - Facebook
Post by Molly Greene Haywood on February 8, 2013
, ✔✔Which entity does not require the IACUC to have a scientific member? - ✔✔USDA
Source: Certified Professional IACUC Administrator (CPIA) Study Group - Facebook
Post by Molly Greene Haywood on March 6, 2013
✔✔Which of the following statements is true about routes of administration for injectable
agents?
a. When performing an IP injection, the drug must also contain a neuromuscular
blocking agent.
b. IV administration produces the slowest loss of consciousness.
c. IC injection is acceptable when the animal is either heavily sedated, anesthetized, or
comatose.
d. IP administration is optimal for irritating euthanasia agents. - ✔✔c. IC injection is
acceptable when the animal is either heavily sedated, anesthetized, or comatose.
Source: AALAS Learning Library
Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia
of Research Animals: AVMA Guidelines
✔✔What is the recommended concentration of carbon monoxide used for euthanasia of
small mammals?
a) Over 10%
b) 8-10%
c) 2-3%
d) 4-6% - ✔✔d) 4-6%
Source: AALAS Learning Library
Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia
of Research Animals: AVMA Guidelines
✔✔Under what circumstance is the IV or IC injection of potassium chloride an
acceptable euthanasia method?
a) When other methods have failed
b) When used in combination with a barbiturate
c) If a catheter is used
d) If the animal is anesthetized - ✔✔d) If the animal is anesthetized
Source: AALAS Learning Library
Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia
of Research Animals: AVMA Guidelines
ANSWERS GRADED A+
✔✔Which of the following is not an example of reduction?
A. The use of a new anesthetic that provides better induction and a shorter recovery
period.
B. The shared use of tissues by more than one investigator to minimize animal use.
C. The use of improved assays that provide better data precision so that fewer animals
are needed per group.
D. The use of common control groups during simultaneous experiments to limit the
number of control animals needed. - ✔✔A. The use of a new anesthetic that provides
better induction and a shorter recovery period.
✔✔Which of the following is not an example of refinement?
A. The use of newer surgical techniques that result in less tissue trauma.
B. The use of a new analgesic that provides better postoperative pain relief.
C. The use of computer modeling software to substitute for animal experiments.
D. The use of a new bleeding technique that causes less pain and distress. - ✔✔C. The
use of computer modeling software to substitute for animal experiments.
✔✔What is required, of the IACUC, by the USDA AWA Regulations regarding
alternatives?
A. Ensure that the limit on animal use assigned to the institution by the USDA is not
exceeded more than once every three years.
B. Reduce animal usage by at least 10% per year over a five-year period.
C. Reduce animal usage by at least 25% over a five-year period.
D. Ensure that the principal investigator has considered alternatives to painful or
distressing procedures, and review a written assurance that alternatives are not
available. - ✔✔D. Ensure that the principal investigator has considered alternatives to
painful or distressing procedures, and review a written assurance that alternatives are
not available.
✔✔What is the basis for the pain/distress classification system used by most
institutions?
A. AAALAC pain/distress categories.
B. PHS pain/distress categories.
C. USDA pain/distress categories.
D. Guide pain/distress categories. - ✔✔C. USDA pain/distress categories.
✔✔Which of the following activities would disqualify an animal from USDA category B?
A. Blood collection.
B. Being placed into new caging.
C. Breeding.
D. Being observed during quarantine. - ✔✔A. Blood collection.
,✔✔Which of the following activities would disqualify an animal from USDA category D?
A. Retroorbital blood collection from a mouse performed under anesthesia.
B. Collecting tail snips from adult rodents for genotyping under local or general
anesthesia.
C. Surgery performed under anesthesia.
D. Studies in which animals are allowed to die without pain relief. - ✔✔D. Studies in
which animals are allowed to die without pain relief.
✔✔An investigator wishes to use animals in an experiment that involves category B, C,
and D activities performed on the same animal. How should the animal be categorized?
A. Categories B, C, and D.
B. Category B.
C. Category C.
D. Category D. - ✔✔D. Category D.
✔✔Which of the following activities would place an animal in category E?
A. Lethal dose experiments in which animals are allowed to die without intervention.
B. Observation studies of normal primate behavior.
C. Blood collection from a superficial vessel of a dog.
D. Major surgery in which anesthetics and postoperative analgesics are administered. -
✔✔A. Lethal dose experiments in which animals are allowed to die without intervention.
✔✔All personnel performing animal procedures must be properly trained to do so
when?
A. By the end of the experiments.
B. Before any procedures are performed.
C. Before any procedures are performed unless they have doctoral level or medical
degrees.
D. Before any procedures are performed unless they receive a waiver from their
supervisor. - ✔✔B. Before any procedures are performed.
✔✔Which statement about the Occupational Health and Safety Program is false?
A. You should enroll in the local Occupational Health and Safety Program before you
begin your work with laboratory animals.
B. Typical services include rabies immunizations, TB testing, and tetanus
immunizations.
C. You may not decline medical treatments provided as part of the Occupational Health
and Safety Program.
D. Each institution must have an Occupational Health and Safety Program for personnel
who have significant contact with laboratory animals. - ✔✔C. You may not decline
medical treatments provided as part of the Occupational Health and Safety Program.
✔✔Which of the following is false concerning prolonged restraint of animals?
A. The restraint method used should be the least restrictive possible that will allow
achievement of experimental objectives.
,B. It can be justified as a convenience for the research staff.
C. The period of restraint should be the minimum required to achieve experimental
objectives.
D. It should not be considered a normal method of housing. - ✔✔B. It can be justified as
a convenience for the research staff.
✔✔Which of the following is true of the dog exercise program mandated by the USDA
Animal Welfare Act regulations?
A. Dogs must be provided additional exercise regardless of the floor area of the cage.
B. The IACUC can exempt an animal for scientific reasons.
C. The veterinarian cannot exempt an animal, even for medical reasons.
D. The veterinarian can exempt an animal for scientific reasons. - ✔✔B. The IACUC can
exempt an animal for scientific
✔✔Great Southern Agricultural and Technical University has an Animal Welfare
Assurance Statement on file with OLAW that covers all PHS funded projects. The
University's policy states that all use of live vertebrate animals for teaching and research
requires IACUC review and approval. A faculty member contacts the IACUC Chair to
report that he demonstrated a blood sampling procedure on a live chicken for a teaching
lab, but it was not the blood sampling method described in the IACUC approved
protocol for the lab. The IACUC must report this noncompliance to:
1) OLAW
2) USDA
3) The University's IO
4) All of the above - ✔✔3) The University's IO
✔✔The institution's PHS Assurance applies to PHS-funded projects only. An
investigator has two IACUC protocols using mice. Protocol A (NIH funded) stipulates
that animals will be killed by barbiturate overdose while decapitation would be the
method used in Protocol B (private foundation funds). The investigator informs the
IACUC Office that his staff mistakenly euthanized a few animals assigned to Protocol B
with barbiturate overdose. How should the IACUC respond?
a) Suspend the investigator.
b) Report to US Department of Agriculture.
c) Report to Office of Laboratory Animal Welfare.
d) Retrain the investigator and staff. - ✔✔a) you could suspend, but it's not required,
and would probably make people mad at the IACUC.
b) reporting noncompliance to the USDA is not required.
c) this institution's Assurance applies to PHS funded activities only therefore reporting
noncompliance on a project not funded by the PHS is not required.
d) probably the best practice to prevent future noncompliance.
Source: Certified Professional IACUC Administrator (CPIA) Study Group - Facebook
Post by Molly Greene Haywood on February 8, 2013
, ✔✔Which entity does not require the IACUC to have a scientific member? - ✔✔USDA
Source: Certified Professional IACUC Administrator (CPIA) Study Group - Facebook
Post by Molly Greene Haywood on March 6, 2013
✔✔Which of the following statements is true about routes of administration for injectable
agents?
a. When performing an IP injection, the drug must also contain a neuromuscular
blocking agent.
b. IV administration produces the slowest loss of consciousness.
c. IC injection is acceptable when the animal is either heavily sedated, anesthetized, or
comatose.
d. IP administration is optimal for irritating euthanasia agents. - ✔✔c. IC injection is
acceptable when the animal is either heavily sedated, anesthetized, or comatose.
Source: AALAS Learning Library
Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia
of Research Animals: AVMA Guidelines
✔✔What is the recommended concentration of carbon monoxide used for euthanasia of
small mammals?
a) Over 10%
b) 8-10%
c) 2-3%
d) 4-6% - ✔✔d) 4-6%
Source: AALAS Learning Library
Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia
of Research Animals: AVMA Guidelines
✔✔Under what circumstance is the IV or IC injection of potassium chloride an
acceptable euthanasia method?
a) When other methods have failed
b) When used in combination with a barbiturate
c) If a catheter is used
d) If the animal is anesthetized - ✔✔d) If the animal is anesthetized
Source: AALAS Learning Library
Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia
of Research Animals: AVMA Guidelines
