NURS 6521N Advanced Pharmacology, NURS 6521N, Walden
University, 2026 – Complete Midterm Exam Questions with
Verified Answers and Pharmacology Study Guide
Introduction
This document contains a comprehensive collection of
Advanced Pharmacology midterm examination questions and
verified answers covering pharmacokinetics,
pharmacodynamics, drug metabolism, adverse drug reactions,
pharmacogenomics, and medication safety principles. It also
reviews major drug classes including diuretics, ACE inhibitors,
antihypertensives, antidysrhythmics, heart failure
medications, respiratory drugs, and lipid-lowering agents.
The material is structured in a question-and-answer format to
support exam preparation and rapid review of core
pharmacology concepts. It includes clinical prescribing
considerations, monitoring requirements, drug interactions,
black box warnings, and disease-specific pharmacotherapy
frequently tested in advanced nursing programs.
Exam Questions and Answers
65.What will the provider consider when prescribing Two
drugs that compete for plasma albumin receptor sites---
correct precise answer --- Binding of one or both agents will
be reduced
Plasma levels of free drug will rise
,66.What are common occurrences in fatal medication errors---
correct precise answer --- Giving a drug intra-venously
instead of IM
Administering a drug that sounds like the prescribed drug
Riding a prescription eligibly
67.What are the three categories of fatal medication errors---
correct precise answer --- Human factors, communi-cation
mistakes, and name confusion
68.What is the most important education to give a patient
taking Flagyl--- correct precise answer --- Should be educated
not to drink alcohol to prevent a disulfiram-like reaction
69.What is disulfiram?--- correct precise answer --- A drug to
discourage alcohol use. Why is it given to alcoholics? It causes
a toxic response when alcohol is consumed.
70.Prescriber actionwill have the greatest impact on the
patient's commitment to adherence to any type of medication
therapy--- correct precise answer --- Providing medication
education the patient can easily understand
71.What is the hepatic microsomal enzyme system--- correct
precise answer --- A family of enzymes that inactivate drugs
and accelerate drug excretion
72.What are the three cytochrome families designated to
metabolize drugs--- correct precise answer --- -
CYP1, CYP2, CYP3
73.What is a pro-drug?--- correct precise answer --- a
biologically inactive compound that can be metabolized in the
body to produce
a drug
,74.What are the three types of drugs--- correct precise
answer --- P450 substrates, p450 enzyme inducers
p450 enzyme inhibitors
75.What are drugs that increase the rate of drug metabolism--
- correct precise answer --- Inducers
76.What is the term first pass effect--- correct precise answer
--- The rapid hepatic inactivation of certain oral drugs
77.What accounts for the majority of drug excretion--- correct
precise answer --- kidneys
78.What are the three processes of urinary excretion---
correct precise answer --- Glomerular filtration Passive
tubular reabsorption
Active tubular secretion
79.What is drug half-life?--- correct precise answer --- the
time required for the amount of drug in the body to decrease
by 50%
80.Non-renal routes of drug excretion--- correct precise
answer --- breast milk, bile, lungs, sweat, saliva
81.What is the largest effect that a drug can produce---
correct precise answer --- maximal eflcacy
82.Any functional macromolecule in a cell to which a drug
binds to produce its effects--- correct precise answer --- A
receptor
83.The more selective a drug is...--- correct precise answer ---
the fewer side ettects it will produce
84.If a drug interacts with several different receptor sites---
correct precise answer --- Then the drug is likely to elicit a
wide variety of responses
, 85.What is the simple occupancy Theory--- correct precise
answer --- States that the intensity of a drug reaction is
dependent on the number of receptors occupied
86.What is the modified occupancy Theory--- correct precise
answer --- States that the intensity of a drug reaction is
dependent on the number of receptors occupied but takes into
consideration of aflnity and intrinsic activity
87.What is a drug affinity--- correct precise answer --- The
force of attraction between a drug and its receptor site The
Aflnity of a drug for its receptor is reflected in its potency.
Drugs with high Aflnity are very potent
88.What is a drug's intrinsic activity?--- correct precise
answer --- The ability of a drug to activate a receptor upon
binding.
Drugs with high intrinsic activity can cause intense receptor
activation.
Drugs with high intrinsic activity have high maximal eflcacy
89.What are the two actions that occur when a drug binds to
its receptor--- correct precise answer --- They can mimic the
action of androgynous regulatory molecules
Or they can block the action of androgynous regulatory
molecules
90.What are agonists and antagonists?--- correct precise
answer --- •Agonists - increase normal activity of a
neurotransmitter
•Antagonists - decrease activity of a neurotransmitter
91.A drug that has both affinity and high intrinsic activity---
correct precise answer --- Agonist
University, 2026 – Complete Midterm Exam Questions with
Verified Answers and Pharmacology Study Guide
Introduction
This document contains a comprehensive collection of
Advanced Pharmacology midterm examination questions and
verified answers covering pharmacokinetics,
pharmacodynamics, drug metabolism, adverse drug reactions,
pharmacogenomics, and medication safety principles. It also
reviews major drug classes including diuretics, ACE inhibitors,
antihypertensives, antidysrhythmics, heart failure
medications, respiratory drugs, and lipid-lowering agents.
The material is structured in a question-and-answer format to
support exam preparation and rapid review of core
pharmacology concepts. It includes clinical prescribing
considerations, monitoring requirements, drug interactions,
black box warnings, and disease-specific pharmacotherapy
frequently tested in advanced nursing programs.
Exam Questions and Answers
65.What will the provider consider when prescribing Two
drugs that compete for plasma albumin receptor sites---
correct precise answer --- Binding of one or both agents will
be reduced
Plasma levels of free drug will rise
,66.What are common occurrences in fatal medication errors---
correct precise answer --- Giving a drug intra-venously
instead of IM
Administering a drug that sounds like the prescribed drug
Riding a prescription eligibly
67.What are the three categories of fatal medication errors---
correct precise answer --- Human factors, communi-cation
mistakes, and name confusion
68.What is the most important education to give a patient
taking Flagyl--- correct precise answer --- Should be educated
not to drink alcohol to prevent a disulfiram-like reaction
69.What is disulfiram?--- correct precise answer --- A drug to
discourage alcohol use. Why is it given to alcoholics? It causes
a toxic response when alcohol is consumed.
70.Prescriber actionwill have the greatest impact on the
patient's commitment to adherence to any type of medication
therapy--- correct precise answer --- Providing medication
education the patient can easily understand
71.What is the hepatic microsomal enzyme system--- correct
precise answer --- A family of enzymes that inactivate drugs
and accelerate drug excretion
72.What are the three cytochrome families designated to
metabolize drugs--- correct precise answer --- -
CYP1, CYP2, CYP3
73.What is a pro-drug?--- correct precise answer --- a
biologically inactive compound that can be metabolized in the
body to produce
a drug
,74.What are the three types of drugs--- correct precise
answer --- P450 substrates, p450 enzyme inducers
p450 enzyme inhibitors
75.What are drugs that increase the rate of drug metabolism--
- correct precise answer --- Inducers
76.What is the term first pass effect--- correct precise answer
--- The rapid hepatic inactivation of certain oral drugs
77.What accounts for the majority of drug excretion--- correct
precise answer --- kidneys
78.What are the three processes of urinary excretion---
correct precise answer --- Glomerular filtration Passive
tubular reabsorption
Active tubular secretion
79.What is drug half-life?--- correct precise answer --- the
time required for the amount of drug in the body to decrease
by 50%
80.Non-renal routes of drug excretion--- correct precise
answer --- breast milk, bile, lungs, sweat, saliva
81.What is the largest effect that a drug can produce---
correct precise answer --- maximal eflcacy
82.Any functional macromolecule in a cell to which a drug
binds to produce its effects--- correct precise answer --- A
receptor
83.The more selective a drug is...--- correct precise answer ---
the fewer side ettects it will produce
84.If a drug interacts with several different receptor sites---
correct precise answer --- Then the drug is likely to elicit a
wide variety of responses
, 85.What is the simple occupancy Theory--- correct precise
answer --- States that the intensity of a drug reaction is
dependent on the number of receptors occupied
86.What is the modified occupancy Theory--- correct precise
answer --- States that the intensity of a drug reaction is
dependent on the number of receptors occupied but takes into
consideration of aflnity and intrinsic activity
87.What is a drug affinity--- correct precise answer --- The
force of attraction between a drug and its receptor site The
Aflnity of a drug for its receptor is reflected in its potency.
Drugs with high Aflnity are very potent
88.What is a drug's intrinsic activity?--- correct precise
answer --- The ability of a drug to activate a receptor upon
binding.
Drugs with high intrinsic activity can cause intense receptor
activation.
Drugs with high intrinsic activity have high maximal eflcacy
89.What are the two actions that occur when a drug binds to
its receptor--- correct precise answer --- They can mimic the
action of androgynous regulatory molecules
Or they can block the action of androgynous regulatory
molecules
90.What are agonists and antagonists?--- correct precise
answer --- •Agonists - increase normal activity of a
neurotransmitter
•Antagonists - decrease activity of a neurotransmitter
91.A drug that has both affinity and high intrinsic activity---
correct precise answer --- Agonist
