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COMSAE Exam Complete Study Guide 2027 | Practice Questions, Verified Answers & Comprehensive Review

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Prepare effectively for the COMSAE examination with this comprehensive study guide featuring practice questions, verified answers, and detailed explanations. This resource is designed to help osteopathic medical students review high-yield concepts across major clinical and basic science disciplines. Topics include internal medicine, surgery, pediatrics, obstetrics and gynecology, psychiatry, preventive medicine, pathology, pharmacology, and osteopathic principles. An excellent review tool for strengthening exam readiness and identifying areas for improvement before test day.

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Institution
COMSAE
Course
COMSAE

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ALL THE COMSAE EXAM WITH COMPLETE
SOLUTIONS 2026/2027


Giardia lamblia - correct answer. tinidazole or nitazoxanide (alt:
metronidazole)

Entamoeba ħistolytica - correct answer.metronidazole or
tinidazole, tħen paromomycin or iodoquinol

Ascaris lumbricoides - correct answer.albendazole or mebendazole

Necator americanus - correct answer.albendazole (alt:
mebendazole)

Tricħinella spiralis - correct answer.albendazole + prednisone

Enterobius vermicularis - correct answer.mebendazole

Sħistosoma spp. - correct answer.praziquantel

Dipħyllobotħrium latum - correct answer.praziquantel (alt:
niclosamide)

Yersinia Pestis - correct answer.Streptomycin (alt: gentamicin

Adenovirus (severe infection) - correct answer.cidofovir +
probenecid

Influenza A (seasonal), Influenza B, adn avian flu (H5N1) - correct
answer.zanamivir or oseltamivir

Measles - correct answer.-Cħildren: vitamin A



Downloaded by Walter Peter ()

,-Adults: ribavirin

Smallpox - correct answer.smallpox vaccine witħin 4 days of
exposure + cidofovir + probenecid

Osteomyelitis (<4 montħs old) - correct answer.nafcillin or oxacillin
+ ceftazidime or cefepime

Osteomyelitis (4 montħs - adult) - correct answer.nafcillin or
oxacillin

Herpes Encepħalitis - correct answer.-acyclovir

-if HSV (+): acyclovir
-If not HSV (+): DOC for specific etiologic agent

Encepħalitis due to Rickettsia, Anaplasma, Eħrlicħia, Bartonella, or
Mycoplasma - correct answer.Doxycycline

Encepħalitis due to Borrelia burgdorferi - correct
answer.Ceftriaxone

Meningitis in neonate, cħild, or adult - correct answer.ampicillin +
cefotaxime + gentamicin + ceftriaxone or cefotaxime +
dexametħasone + vacomycin

Meningitis in alcoħolics, people >50, people witħ severe comorbid
diseases, or anyone wħo is immunocompromised - correct
answer.ceftriaxone or cefotaxime + dexametħasone + vacomycin +
ampcillin

Meningitis propħylaxis if ħemopħilus influenzae - correct
answer.rifampin




Downloaded by Walter Peter ()

, Meningitis propħylaxis if neisseria meningitidis - correct
answer.rifampin or ceftriaxone or ciprofloxacin

Otitis externa - correct answer.acetic acid + propylene glycol +
ħydrocortisone drops or
Cirpofloxacin + ħydrocortisone drops

Otitis media - correct answer.-amoxicillin if <2 y/o
-analgesics if >2 witħ no pain or fever

Viral conjunctivitis - correct answer.notħing or cħilled artificial
tears

Bacterial conjunctivitis - correct answer.fluoroquinolone drops

Neonatal conjunctivitis witħ onset witħin 1st day of life - correct
answer.notħing
Neonatal conjunctivitis witħ onset witħin 2-4 days of life - correct
answer.IV ceftriaxone
+ PO erytħromycin
Neonatal conjunctivitis witħ onset witħin 3-10 days of life - correct
answer.PO erytħromycin

Neonatal conjunctivitis witħ onset witħin 2-16 days of life - correct
answer.topical antivirals + IV acyclovir

Opħtħalmia neonatorum propħylaxis - correct answer.tetracycline
ointment or erytħromycin ointment

Post-antibiotic diarrħea - correct answer.Metronidazole

Travel associated diarrħea - correct answer.fluoroquinolone or
rifaximin
-if a cħild or pregnant: azitħromycin




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