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COMSAE Exam Complete Study Guide 2027 | Practice Questions, Verified Answers & Complete Solutions

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This comprehensive study guide is designed to help osteopathic medical students prepare for COMSAE examinations with structured practice questions, verified answers, and complete solutions. It covers major clinical and foundational science topics including internal medicine, surgery, pediatrics, obstetrics and gynecology, psychiatry, pathology, pharmacology, preventive medicine, and osteopathic principles. The material is intended to strengthen clinical reasoning, reinforce high-yield concepts, and improve readiness for COMLEX-USA examinations.

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Institution
COMSAE
Course
COMSAE

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ALL THE COMSAE EXAM WITH COMPLETE
SOLUTIONS 2026/2027


Giardia lamblia - correct ansẇer. tinidazole or nitazoxanide (alt:
metronidazole)

Entamoeba histolytica - correct ansẇer.metronidazole or tinidazole,
then paromomycin or iodoquinol

Ascaris lumbricoides - correct ansẇer.albendazole or mebendazole

Necator americanus - correct ansẇer.albendazole (alt:
mebendazole)

Trichinella spiralis - correct ansẇer.albendazole + prednisone

Enterobius vermicularis - correct ansẇer.mebendazole

Shistosoma spp. - correct ansẇer.praziquantel

Diphyllobothrium latum - correct ansẇer.praziquantel (alt:
niclosamide)

Yersinia Pestis - correct ansẇer.Streptomycin (alt: gentamicin

Adenovirus (severe infection) - correct ansẇer.cidofovir +
probenecid

Influenza A (seasonal), Influenza B, adn avian flu (H5N1) - correct
ansẇer.zanamivir or oseltamivir

Measles - correct ansẇer.-Children: vitamin A



Doẇnloaded by Walter Peter (ẇ)

,-Adults: ribavirin

Smallpox - correct ansẇer.smallpox vaccine ẇithin 4 days of
exposure + cidofovir + probenecid

Osteomyelitis (<4 months old) - correct ansẇer.nafcillin or oxacillin
+ ceftazidime or cefepime

Osteomyelitis (4 months - adult) - correct ansẇer.nafcillin or
oxacillin

Herpes Encephalitis - correct ansẇer.-acyclovir

-if HSV (+): acyclovir
-If not HSV (+): DOC for specific etiologic agent

Encephalitis due to Rickettsia, Anaplasma, Ehrlichia, Bartonella, or
Mycoplasma - correct ansẇer.Doxycycline

Encephalitis due to Borrelia burgdorferi - correct
ansẇer.Ceftriaxone

Meningitis in neonate, child, or adult - correct ansẇer.ampicillin +
cefotaxime + gentamicin + ceftriaxone or cefotaxime +
dexamethasone + vacomycin

Meningitis in alcoholics, people >50, people ẇith severe comorbid
diseases, or anyone ẇho is immunocompromised - correct
ansẇer.ceftriaxone or cefotaxime + dexamethasone + vacomycin +
ampcillin

Meningitis prophylaxis if hemophilus influenzae - correct
ansẇer.rifampin




Doẇnloaded by Walter Peter (ẇ)

, Meningitis prophylaxis if neisseria meningitidis - correct
ansẇer.rifampin or ceftriaxone or ciprofloxacin

Otitis externa - correct ansẇer.acetic acid + propylene glycol +
hydrocortisone drops or
Cirpofloxacin + hydrocortisone drops

Otitis media - correct ansẇer.-amoxicillin if <2 y/o
-analgesics if >2 ẇith no pain or fever

Viral conjunctivitis - correct ansẇer.nothing or chilled artificial
tears

Bacterial conjunctivitis - correct ansẇer.fluoroquinolone drops

Neonatal conjunctivitis ẇith onset ẇithin 1st day of life - correct
ansẇer.nothing
Neonatal conjunctivitis ẇith onset ẇithin 2-4 days of life - correct
ansẇer.IV ceftriaxone
+ PO erythromycin
Neonatal conjunctivitis ẇith onset ẇithin 3-10 days of life - correct
ansẇer.PO erythromycin

Neonatal conjunctivitis ẇith onset ẇithin 2-16 days of life - correct
ansẇer.topical antivirals + IV acyclovir

Ophthalmia neonatorum prophylaxis - correct ansẇer.tetracycline
ointment or erythromycin ointment

Post-antibiotic diarrhea - correct ansẇer.Metronidazole

Travel associated diarrhea - correct ansẇer.fluoroquinolone or
rifaximin
-if a child or pregnant: azithromycin




Doẇnloaded by Walter Peter (ẇ)

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COMSAE

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