MIMG C185A Final Exam | Questions and Answers | 2025 Revised Update | 100% Correct - UCLA.

MIMG C185A Final Exam | Questions and
Answers | 2025 Revised Update | 100% Correct -
UCLA.

Immunology
MIMG 185A
Final examination
6/8/2020
3 hours and 45 minutes

Question 1 / 20
Question 2 / 120
Question 3 / 60
Question 4 / 100
Question 5 / 100
Question 6 / 100
Bonus Question / 25
Total / 500

,Question 1: (20 points)
Some autoimmune diseases are characterized by the production of antibodies of IgG
isotype that are specific for DNA. Knowing that B cells need T cell help for proper
activation and isotype class switching and that DNA cannot be presented on MHCs to T
cells, how would you explain this phenomenon? (1-2 sentences)




Question 2 (120 points):
2A. Write down how each particular gene knock out (KO) affects mouse immune
responses to bacteria and parasitic worms. Use + for full response, +/- for partial
response and – for no response. (24 points total)

Response to
(extracellular) bacteria Response to
Type of mouse KO
parasitic worms
IgM IgG
Surrogate light chain
KO
RAG1/2 KO

β2 microglobulin

Iε KO

Pre-TCRα (gp33) KO

Igα/Igβ KO

AID KO

CD28 KO




1

, Explain your answers and make sure to address the immune responses against both
types of pathogens.

a) Surrogate light chain KO (5 points)




b) RAG1/2 KO (5 points)




c) p2 microglobulin (5 points)




d) Iε KO (5 points)




e) Pre-TCRα (gp33) KO (5 points)




f) Igα/Igp KO (5 points)




g) AID KO (5 points)




2