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Miami University
Importance of infectious diseases to community health? - ANSWERS--death
-illness
-economic costs (lost worker/student productivity, prevention
measures/program, outbreak control measures, health care costs, some
infectious diseases cause long term disabilities)
Principles of Disease Transmission: Chain of infection - ANSWERS-
Pathogen...Reservoir...Portal of exit....Transmission...Portal of entry...
Establishment of infection in new host
Reservoirs of Infection - ANSWERS--natural host or habitat of a pathogenic
microbe
-place(s) where the pathogenic microbe normally lives/multiplies
Human Reservoirs - ANSWERS--people with CLINICALLY RECOGNIZED DISEASE
(have signs and symptoms)
Carriers - ANSWERS-disease is SUBCLINICAL (no signs or symptoms) but
pathogenic microbes ARE INCONSPICUOUSLY harbored and shed to others:
-certain infectious diseases rarely involve signs or symptoms
,-during incubation or convalescent periods of infectious disease process
-certain infectious diseases result in a chronic carrier state
-passive carriers are not infected but spread pathogens on contaminated hands,
clothing, etc.
Animal Reservoirs - ANSWERS-Zoonoses: diseases that occur primarily in wild or
domestic animals that can be transmitted to humans
Nonliving Reservoirs - ANSWERS-food, water, soil
Direct Contact Transmission - ANSWERS-microbes spread by direct physical
contact between source and host (no intermediate objects)
Transmission by Droplets - ANSWERS-microbes spread in mucus droplets (from
sneezing, coughing, talking) that travel less than 1 meter
Vertical transmission - ANSWERS-microbes cross placenta from mother to fetus
Transmission by Vectors (vector-borne diseases) - ANSWERS-Vector: nonhuman,
living organism capable of transmitting pathogenic microbes
(ex: most are arthropods like ticks mosquitoes, flies, etc) and can also be animals
such as rodents
Transmission by Vehicles - ANSWERS-Vehicle: nonliving material capable of
transmitting infectious disease (water, food, or air borne diseases or fomites)
,Air-borne diseases: microbes in droplet nuclei from fine spray from sneezing,
coughing, or carried by water aerosols or by soil dust
Fomites: contaminated objects (bedding, dishes, toys, cell phones, medical
equipment, etc.)
Portals of entry and exit - ANSWERS--pathogenic microbes have definite routes of
entry and exit from infected hosts (mucous membranes or broken skin)
Principles of Infectious Disease - ANSWERS--infection
-pathogenicity
-virulence
-virulence factors
Infection - ANSWERS-entry, establishment, and multiplication of microbes within
a host organism
Pathogenicity - ANSWERS-ability of microbes to cause disease in a host organism
Virulence - ANSWERS-level of pathogenicity (how bad is the bug?)
Virulence Factor - ANSWERS-any characteristic that assists a microbe in causing
disease
-they are molecules or cell structures that
, - allow microbial ATTACHMENT to host cells and/or allow IMMUNE SYSTEM
EVASION by the microbe and/or DAMAGE THE HOST ORGANISM either directly or
indirectly
-virulence factor depends on its particular arsenal of virulence factors
-damage done by certain virulence factors can be life-threatening
Pertussis - ANSWERS-an example of the chain of infection & roles of virulence
factors in an infectious disease of community health importance
pathogenic microbe: bordatella pertussis bacteria
reservoir: infected humans (clinical cases & carriers)
modes of transmission: airborne transmission or direct transmission by droplets
from coughing & sneezing of infected people
the bacteria bind tightly to cells in the throat and multiply there
virulence factor: filamentous hemagglutinin (FHA) molecules on the surface of B.
pertussis attach to receptors on throat epithelial cells
as the bacteria multiply in the throat, virulence factors begin to affect the host
virulence factor: Endotoxin (lipid A)