COMSAE PHASE 1 (FORM 115) EXAM – QUESTIONS AND ANSWERS | VERIFIED AND
WELL DETAILED ANSWERS | PLUS RATIONALES | GUARANTEED PASS | LATEST
EXAM UPDATE
*CORE DOMAINS*
*1. Osteopathic Principles and Practice*
*2. Biomedical Sciences (Anatomy, Physiology, Biochemist
*3. Pathology and Pathophysiology*
*4. Pharmacology and Therapeutics*
*5. Clinical Decision Making and Diagnosis*
*6. Ethics, Legal, and Professional Standards*
*7. Public Health and Preventive Medicine*
*8. Behavioral Science and Patient Communication*
*INTRODUCTION*
*The COMSAE Phase 1 (Form 115) exam is designed to evaluate a student's foundational knowle
SECTION ONE: QUESTIONS 1–100
,1. A 45-year-old male presents with acute lower back pain after lifting a heavy box.
Physical examination reveals a somatic dysfunction at L2 with a rotation to the right.
Which of the following is the appropriate segment to treat using muscle energy
techniques if the dysfunction is T12-L2 rotated right?
A. T12
B. L1
C. L2
D. L3
🟢 Correct answer: C
🔴 Explanation: Muscle energy treatment for a specific vertebral segment dysfunction is
directed at the segment exhibiting the primary somatic dysfunction. Since L2 is the segment
identified with rotation, it is the focus of the treatment.
2. Which of the following neurotransmitters is primarily responsible for the postganglionic
sympathetic innervation to the eccrine sweat glands?
A. Acetylcholine
B. Norepinephrine
C. Dopamine
D. Serotonin
🟢 Correct answer: A
,🔴 Explanation: Although most sympathetic postganglionic fibers release norepinephrine,
sympathetic fibers innervating eccrine sweat glands are a notable exception, releasing
acetylcholine to bind to muscarinic receptors.
3. A patient with a history of hypertension is started on an ACE inhibitor. Which of the
following electrolyte abnormalities is a known potential side effect?
A. Hypokalemia
B. Hyperkalemia
C. Hyponatremia
D. Hypercalcemia
🟢 Correct answer: B
🔴 Explanation: ACE inhibitors decrease the production of aldosterone, which normally
promotes the excretion of potassium. Therefore, a reduction in aldosterone leads to
potassium retention.
4. An osteopathic physician identifies a "flat" occiput and a restricted range of motion in
the craniosacral mechanism. Which cranial strain pattern is most likely associated with
a decrease in the amplitude of the CRI?
A. Vertical strain
B. Lateral strain
, C. Compression of the occipital condyles
D. Torsion
🟢 Correct answer: C
🔴 Explanation: Compression of the occipital condyles is characterized by a lack of motion
in the craniosacral mechanism, often resulting from trauma to the head and leading to a
significant decrease in the amplitude of the cranial rhythmic impulse.
5. A 60-year-old female presents with fatigue and elevated alkaline phosphatase. Further
testing shows an elevated anti-mitochondrial antibody (AMA). What is the most likely
diagnosis?
A. Primary Sclerosing Cholangitis
B. Primary Biliary Cholangitis
C. Autoimmune Hepatitis
D. Alcoholic Cirrhosis
🟢 Correct answer: B
🔴 Explanation: The presence of anti-mitochondrial antibodies is highly specific and
sensitive for the diagnosis of Primary Biliary Cholangitis (formerly Primary Biliary Cirrhosis).
6. Which anatomical structure is responsible for the transition of the midgut to the hindgut
in the developing fetus?
WELL DETAILED ANSWERS | PLUS RATIONALES | GUARANTEED PASS | LATEST
EXAM UPDATE
*CORE DOMAINS*
*1. Osteopathic Principles and Practice*
*2. Biomedical Sciences (Anatomy, Physiology, Biochemist
*3. Pathology and Pathophysiology*
*4. Pharmacology and Therapeutics*
*5. Clinical Decision Making and Diagnosis*
*6. Ethics, Legal, and Professional Standards*
*7. Public Health and Preventive Medicine*
*8. Behavioral Science and Patient Communication*
*INTRODUCTION*
*The COMSAE Phase 1 (Form 115) exam is designed to evaluate a student's foundational knowle
SECTION ONE: QUESTIONS 1–100
,1. A 45-year-old male presents with acute lower back pain after lifting a heavy box.
Physical examination reveals a somatic dysfunction at L2 with a rotation to the right.
Which of the following is the appropriate segment to treat using muscle energy
techniques if the dysfunction is T12-L2 rotated right?
A. T12
B. L1
C. L2
D. L3
🟢 Correct answer: C
🔴 Explanation: Muscle energy treatment for a specific vertebral segment dysfunction is
directed at the segment exhibiting the primary somatic dysfunction. Since L2 is the segment
identified with rotation, it is the focus of the treatment.
2. Which of the following neurotransmitters is primarily responsible for the postganglionic
sympathetic innervation to the eccrine sweat glands?
A. Acetylcholine
B. Norepinephrine
C. Dopamine
D. Serotonin
🟢 Correct answer: A
,🔴 Explanation: Although most sympathetic postganglionic fibers release norepinephrine,
sympathetic fibers innervating eccrine sweat glands are a notable exception, releasing
acetylcholine to bind to muscarinic receptors.
3. A patient with a history of hypertension is started on an ACE inhibitor. Which of the
following electrolyte abnormalities is a known potential side effect?
A. Hypokalemia
B. Hyperkalemia
C. Hyponatremia
D. Hypercalcemia
🟢 Correct answer: B
🔴 Explanation: ACE inhibitors decrease the production of aldosterone, which normally
promotes the excretion of potassium. Therefore, a reduction in aldosterone leads to
potassium retention.
4. An osteopathic physician identifies a "flat" occiput and a restricted range of motion in
the craniosacral mechanism. Which cranial strain pattern is most likely associated with
a decrease in the amplitude of the CRI?
A. Vertical strain
B. Lateral strain
, C. Compression of the occipital condyles
D. Torsion
🟢 Correct answer: C
🔴 Explanation: Compression of the occipital condyles is characterized by a lack of motion
in the craniosacral mechanism, often resulting from trauma to the head and leading to a
significant decrease in the amplitude of the cranial rhythmic impulse.
5. A 60-year-old female presents with fatigue and elevated alkaline phosphatase. Further
testing shows an elevated anti-mitochondrial antibody (AMA). What is the most likely
diagnosis?
A. Primary Sclerosing Cholangitis
B. Primary Biliary Cholangitis
C. Autoimmune Hepatitis
D. Alcoholic Cirrhosis
🟢 Correct answer: B
🔴 Explanation: The presence of anti-mitochondrial antibodies is highly specific and
sensitive for the diagnosis of Primary Biliary Cholangitis (formerly Primary Biliary Cirrhosis).
6. Which anatomical structure is responsible for the transition of the midgut to the hindgut
in the developing fetus?
