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Terms in this set (409)
What happens to nerve tissue during Nerve tissue struggles with anaerobic metabolism
ischemia? and is very sensitive to decreased oxygen.
What is ischemia? Cell death.
What is hypoxia? Decreased oxygen leading to mitochondrial failure
and cell damage.
What is the main CNS Glutamate.
neurotransmitter?
, What effect does ischemia have on Ischemia increases glutamate release.
glutamate?
What are the effects of too much Increased calcium and water enter the cell, causing
glutamate? calcium overload and cytotoxic edema.
What does excessive glutamate Increased production of nitrous oxide, free radical
production lead to? formation, and cell death.
What is the normal range for 0-15 mmHg
intracranial pressure (ICP)?
At what ICP level does brain > 22 mmHg for > 5 minutes
impairment occur?
What are the three main components Brain, Cerebrospinal Fluid (CSF), Blood
of the cranial cavity according to the
Monroe-Kellie doctrine?
What is intracranial compliance? The ability of the cranial components to adjust to
changes in volume to minimize impact on ICP.
Name an everyday activity that can Sneeze, cough, bending, laugh
cause slight changes in ICP.