IgCP Exam – Composition of Ig Products | Study Guide, Practice Questions &
Exam Review
What type of Ig Product s/b avoided in a pt with cardiovascular disease - correct answer
✔✔High sodium product – Asceniv/Bivi gam/Gamma Gard SD
What is the IgA content range of Ig Products? - correct answer ✔✔< 1 mcg/mL to 2000 mcg/mL
What do all Ig products have in their PI regarding IgA? - correct answer ✔✔Contraindication
regarding the administration of Ig products in IgA-deficient patients with antibodies to IgA and a
history of hypersensitivity.
When is the risk the highest for anaphylaxis regarding IgA? - correct answer ✔✔In patients with
undetectable levels
of IgA, anti-A antibodies of the IgE type, and the absence of IgA-positive B cells.
Is SCIG relatively safe in the patients with undetectable levels
of IgA, anti-A antibodies of the IgE type, and the absence of IgA-positive B cells. - correct answer
✔✔Yes
What is the concentration of most commercially available IVIG products? - correct answer
✔✔Ready to use liquid 5% or 10%
What product is available as lyophilized powder and what is the concentration? - correct answer
✔✔Gammagard SD
Can be reconstituted to a 5% or 10% solution, although
the 5% dilution is preferred due to the high osmolality of the solution at its 10% concentration.
, What concentration is preferred in fluid restricted patients and what are some examples of
those patients? - correct answer ✔✔10% (less volume)
Neonates
Pts with renal impairment
Congestive Heart Failure pts
Significant lung impairment
What is recommended with Ig products if patients are not fluid restricted and why? - correct
answer ✔✔Hydration
Lessens ADRs such as HA, nausea, flu-like sx, post infusion HA
What is specific to the patient with regards to Ig products? - correct answer ✔✔Rate of infusion
Product itself
Does a 5% product always take more time to infuse than the 10% - correct answer ✔✔It's
possible for a 5% solution to be administered to a patient more quickly than a 10% product if
the 5% product is better tolerated.
What is the main difference between 5 and 10% Ig products - correct answer ✔✔The volume
administered
Why are stabilizers used in Ig products? - correct answer ✔✔To prevent aggregation of the Igs
Aggregates have been shown to cause some ADRs
Exam Review
What type of Ig Product s/b avoided in a pt with cardiovascular disease - correct answer
✔✔High sodium product – Asceniv/Bivi gam/Gamma Gard SD
What is the IgA content range of Ig Products? - correct answer ✔✔< 1 mcg/mL to 2000 mcg/mL
What do all Ig products have in their PI regarding IgA? - correct answer ✔✔Contraindication
regarding the administration of Ig products in IgA-deficient patients with antibodies to IgA and a
history of hypersensitivity.
When is the risk the highest for anaphylaxis regarding IgA? - correct answer ✔✔In patients with
undetectable levels
of IgA, anti-A antibodies of the IgE type, and the absence of IgA-positive B cells.
Is SCIG relatively safe in the patients with undetectable levels
of IgA, anti-A antibodies of the IgE type, and the absence of IgA-positive B cells. - correct answer
✔✔Yes
What is the concentration of most commercially available IVIG products? - correct answer
✔✔Ready to use liquid 5% or 10%
What product is available as lyophilized powder and what is the concentration? - correct answer
✔✔Gammagard SD
Can be reconstituted to a 5% or 10% solution, although
the 5% dilution is preferred due to the high osmolality of the solution at its 10% concentration.
, What concentration is preferred in fluid restricted patients and what are some examples of
those patients? - correct answer ✔✔10% (less volume)
Neonates
Pts with renal impairment
Congestive Heart Failure pts
Significant lung impairment
What is recommended with Ig products if patients are not fluid restricted and why? - correct
answer ✔✔Hydration
Lessens ADRs such as HA, nausea, flu-like sx, post infusion HA
What is specific to the patient with regards to Ig products? - correct answer ✔✔Rate of infusion
Product itself
Does a 5% product always take more time to infuse than the 10% - correct answer ✔✔It's
possible for a 5% solution to be administered to a patient more quickly than a 10% product if
the 5% product is better tolerated.
What is the main difference between 5 and 10% Ig products - correct answer ✔✔The volume
administered
Why are stabilizers used in Ig products? - correct answer ✔✔To prevent aggregation of the Igs
Aggregates have been shown to cause some ADRs
