MIMG 185 Final Exam
Comprehensive Questions
(Frequently Tested) and Complete
Solutions Graded A+
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What role does B cells play in? - Answer: - Innate and adaptive
immunity
,What are the 3 known subsets of B cells and what immunity do they
play in? - Answer: - B1: Innate immunity
- B2 (conventional): Adaptive Immunity
- Marginal Zone B cells: Innate and Adaptive immunity
What subsets is B-1 B cells divided into and what do they both contain?
- Answer: - B-1a expressing protein CD5
- B-1b that do not express CD5
- Both are high in IgM
- Important to know B-1 B cells sometimes express CD5 (marker for T
cells)
Describe B-1 B cells and their location? - Answer: - Long-lived and self-
renewing
- Develops early in ontogeny from fetal omentum and liver
- After birth, stems cell for B-1 are NOT present in bone marrow
- In adults, they are found predominately in peritoneal and pleural
cavities
- Rare in spleen and absent from lymph node and peripheral blood
Describe the variability of the B-1 B cells and what they produce -
Answer: - Limited V region repertoire
,- Lots of self-reactivity
- Recognition of bacterial antigens (phosphorylcholine)
- Broad specificity and low affinity
- Produce specifities encoded in germline with no N region insertion
and little somatic mutation
- Produce large amounts of antibody (>50% of all antibodies in serume)
- Responsible for majority of non-immune serum IgM and constribute
to resting IgA
- If you immunize your reaction, there will be IgM present that is non-
immune cause of B-1 B cells
What type of responses does B-1 B cells have and do they require T cell
help? - Answer: - Does not require T cell help
- TI-2: make antibody response to polysaccharide Ags found on bacteria
- Plays role in innate response to infection (Abs mostly germline
encoded)
- Rapid response: Makes Abs within 48 hours of antigen exposure (due
to bacterial antigen)
- Without T cell help, do not isotype switch (although some IgA) and no
memory
, What is the origin of B-1 B cells and what role does it play in
autoimmune disease? - Answer: - Hypothesized to be primitive B cells
- In mice, at birth predominately B-1 but later B-2 dominates
- Abundant in autoimmune disease (specficity is often self-reactive)
- B-1 cells origin for human chronic lymphocytic leukemia, typically
express CD5
B-2 B cells arise from where and how do they generate and play a role
in the immune response? - Answer: - Principle B cells in secondary
lymphoid organs (spleen, lymph nodes)
- Arise from fetal liver and bone marrow in adult
- Stem cells continually generate
- Principal B cells in adaptive immune response
Explain the variability of B-2 cells and if they need T cell help or not? -
Answer: - Have extensive variable region repertoire generated
somatically
- Requires T cell help, therefore have isotype swtich and memory
- Recirculates through B cell rich lymphoide follicles
- TD antigen responses in germinal center
Comprehensive Questions
(Frequently Tested) and Complete
Solutions Graded A+
Professional Academic Assistance Services
Services Offered
• Proctored Exam Assistance
• Online Class Management (Full Course Support)
• Exam Preparation & Study Materials
• Assignments and Coursework Support
• Essay and Research Paper Writing
• Discussion Posts & Responses
• Editing and Proofreading
• Confidential Academic Consultation
Contact Information
Email:
WhatsApp link: https://wa.me/254704846336
Fast Response | Confidential | Reliable Academic Support
Helping Students Achieve Academic Excellence
What role does B cells play in? - Answer: - Innate and adaptive
immunity
,What are the 3 known subsets of B cells and what immunity do they
play in? - Answer: - B1: Innate immunity
- B2 (conventional): Adaptive Immunity
- Marginal Zone B cells: Innate and Adaptive immunity
What subsets is B-1 B cells divided into and what do they both contain?
- Answer: - B-1a expressing protein CD5
- B-1b that do not express CD5
- Both are high in IgM
- Important to know B-1 B cells sometimes express CD5 (marker for T
cells)
Describe B-1 B cells and their location? - Answer: - Long-lived and self-
renewing
- Develops early in ontogeny from fetal omentum and liver
- After birth, stems cell for B-1 are NOT present in bone marrow
- In adults, they are found predominately in peritoneal and pleural
cavities
- Rare in spleen and absent from lymph node and peripheral blood
Describe the variability of the B-1 B cells and what they produce -
Answer: - Limited V region repertoire
,- Lots of self-reactivity
- Recognition of bacterial antigens (phosphorylcholine)
- Broad specificity and low affinity
- Produce specifities encoded in germline with no N region insertion
and little somatic mutation
- Produce large amounts of antibody (>50% of all antibodies in serume)
- Responsible for majority of non-immune serum IgM and constribute
to resting IgA
- If you immunize your reaction, there will be IgM present that is non-
immune cause of B-1 B cells
What type of responses does B-1 B cells have and do they require T cell
help? - Answer: - Does not require T cell help
- TI-2: make antibody response to polysaccharide Ags found on bacteria
- Plays role in innate response to infection (Abs mostly germline
encoded)
- Rapid response: Makes Abs within 48 hours of antigen exposure (due
to bacterial antigen)
- Without T cell help, do not isotype switch (although some IgA) and no
memory
, What is the origin of B-1 B cells and what role does it play in
autoimmune disease? - Answer: - Hypothesized to be primitive B cells
- In mice, at birth predominately B-1 but later B-2 dominates
- Abundant in autoimmune disease (specficity is often self-reactive)
- B-1 cells origin for human chronic lymphocytic leukemia, typically
express CD5
B-2 B cells arise from where and how do they generate and play a role
in the immune response? - Answer: - Principle B cells in secondary
lymphoid organs (spleen, lymph nodes)
- Arise from fetal liver and bone marrow in adult
- Stem cells continually generate
- Principal B cells in adaptive immune response
Explain the variability of B-2 cells and if they need T cell help or not? -
Answer: - Have extensive variable region repertoire generated
somatically
- Requires T cell help, therefore have isotype swtich and memory
- Recirculates through B cell rich lymphoide follicles
- TD antigen responses in germinal center
