What is NOT a short or rapid-acting insulin?
Glulisine
Aspart
Regular
Lispro
Glargine
Glargine
How does the lipophilicity of a drug affect its efficacy?
, A higher lipophilicity leads to a higher membrane permeability and metabolic
clearance of the drug.
What is the definition of pharmacodynamics?
The effect of drugs on the body
Which phase is most concerned with drug absorption and metabolism?
Pharmacokinetic phase
What best describes the different formulations of 5-aminosalicylates (5-ASA)?
The different formulations are administered in distinct ways and target
different segments of the bowel.
Considerations of Oral Administration
, Oral administration of medication is a convenient, cost-effective, and most
commonly used medication administration route. The primary site of drug
absorption is usually the small intestine, and the bioavailability of the
medication is influenced by the amount of drug absorbed across the intestinal
epithelium. The first-pass effect is an important consideration for orally
administered medications.
What best describes EC50?
The effective concentration of a drug produces 50% of the maximal effect.
In pharmacodynamics, what term is defined as the biggest effect that a medication can
have in the body?
Maximal efficacy
Phenobarbital should be avoided in which types of seizure?
Give this one a try later!
, Absence seizures
Where is the site of action of neuromuscular blockers?
Give this one a try later!
Postsynaptically at acetylcholine receptors of the motor nerve end plate
Advantages and Disadvantages of Sublingual and Buccal Administration
Give this one a try later!
Advantages:
•Rapid absorption is due to the abundant mucosal network of systemic veins
and lymphatics, thereby leading to a rapid onset of action.
•If there is any untoward event, the tablet can be removed.
•Avoids first-pass hepatic metabolism.
•A tablet can be kept for a long time in the buccal cavity, which helps develop
formulations with a sustained-release effect.
•This route is useful in patients having swallowing difficulties.
•Low risk of infection
•Convenience
Disadvantages:
•The tablet must be kept in the buccal cavity and neither chewed nor
swallowed.
•Excessive salivation may cause quick dissolution and absorption of the tablet.
•Patients may find it difficult to accept an unpalatable tablet. Hence some
drugs are applied as a patch or a spray.
Glulisine
Aspart
Regular
Lispro
Glargine
Glargine
How does the lipophilicity of a drug affect its efficacy?
, A higher lipophilicity leads to a higher membrane permeability and metabolic
clearance of the drug.
What is the definition of pharmacodynamics?
The effect of drugs on the body
Which phase is most concerned with drug absorption and metabolism?
Pharmacokinetic phase
What best describes the different formulations of 5-aminosalicylates (5-ASA)?
The different formulations are administered in distinct ways and target
different segments of the bowel.
Considerations of Oral Administration
, Oral administration of medication is a convenient, cost-effective, and most
commonly used medication administration route. The primary site of drug
absorption is usually the small intestine, and the bioavailability of the
medication is influenced by the amount of drug absorbed across the intestinal
epithelium. The first-pass effect is an important consideration for orally
administered medications.
What best describes EC50?
The effective concentration of a drug produces 50% of the maximal effect.
In pharmacodynamics, what term is defined as the biggest effect that a medication can
have in the body?
Maximal efficacy
Phenobarbital should be avoided in which types of seizure?
Give this one a try later!
, Absence seizures
Where is the site of action of neuromuscular blockers?
Give this one a try later!
Postsynaptically at acetylcholine receptors of the motor nerve end plate
Advantages and Disadvantages of Sublingual and Buccal Administration
Give this one a try later!
Advantages:
•Rapid absorption is due to the abundant mucosal network of systemic veins
and lymphatics, thereby leading to a rapid onset of action.
•If there is any untoward event, the tablet can be removed.
•Avoids first-pass hepatic metabolism.
•A tablet can be kept for a long time in the buccal cavity, which helps develop
formulations with a sustained-release effect.
•This route is useful in patients having swallowing difficulties.
•Low risk of infection
•Convenience
Disadvantages:
•The tablet must be kept in the buccal cavity and neither chewed nor
swallowed.
•Excessive salivation may cause quick dissolution and absorption of the tablet.
•Patients may find it difficult to accept an unpalatable tablet. Hence some
drugs are applied as a patch or a spray.
