QUESTIONS AND ANSWERS GRADED A+
◉ Which neurotransmitter is most involved in chemotherapy-
induced nausea? Answer: Serotonin
◉ What are the indications for Ondansetron? Answer:
Chemotherapy-induced nausea, post-operative nausea,
gastroenteritis.
◉ What is a common adverse effect of Ondansetron? Answer:
Headache
◉ What should be monitored in high-risk patients taking
Ondansetron? Answer: ECG
◉ What class of drug is Prochlorperazine (Compazine)? Answer:
Dopamine (D2) antagonist
◉ What unique action does Metoclopramide (Reglan) have? Answer:
Increases gastric emptying and LES tone.
, ◉ What is a black box warning associated with Metoclopramide?
Answer: Tardive dyskinesia with long-term use.
◉ Which antiemetic is effective for motion sickness? Answer:
Meclizine or Dimenhydrinate
◉ What class of drug is Scopolamine? Answer: Antimuscarinic
◉ What is a common side effect of Scopolamine? Answer: Dry mouth
◉ What route is Scopolamine administered? Answer: Transdermal
patch (behind ear)
◉ What condition should caution the use of Scopolamine? Answer:
Glaucoma
◉ What is the mechanism of action for serotonin antagonists?
Answer: They block serotonin in the GI tract and CTZ.
◉ What is the primary indication for dopamine antagonists?
Answer: Severe nausea/vomiting.
◉ Which antiemetic improves gastric motility? Answer:
Metoclopramide