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What is the time frame in which SUB-ACUTE ALF happens in
regards to jaundice?
What causes it?
Rates of transplant-free
survival? How does the pt
present?
Subacute ALF:
21 days -26 weeks after the onset of jaundice.
Typical causes are drug induced or
indeterminate, Lower transplant-free survival,
Less marked coagulopathy and encephalopathy at presentation
,Diagnostic work-up table.
What is the difference between hematochezia and melena?
1 L of blood needed in stomach to cause hematochezia (bright
red)
50-100 mL is needed to cause melena (dark)
,How does the U.S. Acute Liver Failure Study Group and the
American Association for the Study of Liver Diseases define acute
liver failure?
coagulopathy (INR of >1.5 )
Any degree of mental alteration (encephalopathy) in a patient
without preexisting liver failure
illness duration <26 weeks
(((UNEXPLAINED elevated INR & encephalopathy= very
specific for ALF)))
How do we classify acute liver failure?
Hyperacute ALF
Acute ALF:
Subacute ALF:
, What is the time frame in which HYPER-Acute ALF happens in
regards to jaundice?
What causes it?
Rates of transplant-free
survival? How does the pt
present?
Hyperacute ALF:
Encephalopathy <7 days after the onset of
jaundice. Caused by APAP toxicity &
ischemic hepatitis Higher rates of
transplant-free survival
Patients tend to have high-degree encephalopathy at
presentation and a higher incidence of cerebral edema, albeit a
better prognosis overall