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Comprehensive Osteopathic Medical Self-Assessment Examination (COMSAE) Questions and Answers With Complete Verified Solutions

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This study resource helps students prepare for the Comprehensive Osteopathic Medical Self-Assessment Examination (COMSAE) through comprehensive Questions and Answers with verified solutions. It is designed to strengthen medical knowledge and improve examination readiness. Topics include parasitology, infectious diseases, pharmacology, microbiology, clinical medicine, diagnosis and treatment protocols, osteopathic medical concepts, and high-yield board examination content. Ideal for medical students preparing for COMSAE and COMLEX examinations.

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Institution
COMSAE
Course
COMSAE

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ALL THE COMSAE EXAM WITH COMPLETE
SOLUTIONS 2026/2027


Giardia lamblia - correct answer. tinidazole or nitazoxanide (alt: metronidazole)

Entamoeba histolytica - correct answer.metronidazole or tinidazole, then
paromomycin or iodoquinol

Ascaris lumbricoides - correct answer.albendazole or mebendazole

Necator americanus - correct answer.albendazole (alt: mebendazole)

Trichinella spiralis - correct answer.albendazole + prednisone

Enterobius vermicularis - correct answer.mebendazole Shistosoma

spp. - correct answer.praziquantel

Diphyllobothrium latum - correct answer.praziquantel (alt: niclosamide)

Yersinia Pestis - correct answer.Streptomycin (alt: gentamicin

Adenovirus (severe infection) - correct answer.cidofovir + probenecid

Influenza A (seasonal), Influenza B, adn avian flu (H5N1) - correct
answer.zanamivir or oseltamivir




Measles - correct answer.-Children: vitamin A



Downloaded by Walter Peter ()

,-Adults: ribavirin

Smallpox - correct answer.smallpox vaccine within 4 days of exposure +
cidofovir + probenecid

Osteomyelitis (<4 months old) - correct answer.nafcillin or oxacillin
+ ceftazidime or cefepime

Osteomyelitis (4 months - adult) - correct answer.nafcillin or oxacillin

Herpes Encephalitis - correct answer.-acyclovir

-if HSV (+): acyclovir
-If not HSV (+): DOC for specific etiologic agent

Encephalitis due to Rickettsia, Anaplasma, Ehrlichia, Bartonella, or Mycoplasma
- correct answer.Doxycycline

Encephalitis due to Borrelia burgdorferi - correct answer.Ceftriaxone

Meningitis in neonate, child, or adult - correct answer.ampicillin +
cefotaxime + gentamicin + ceftriaxone or cefotaxime + dexamethasone
+ vacomycin

Meningitis in alcoholics, people >50, people with severe comorbid diseases, or
anyone who is immunocompromised - correct answer.ceftriaxone or cefotaxime
+ dexamethasone + vacomycin + ampcillin

Meningitis prophylaxis if hemophilus influenzae - correct answer.rifampin




Downloaded by Walter Peter

, Meningitis prophylaxis if neisseria meningitidis - correct answer.rifampin
or ceftriaxone or ciprofloxacin

Otitis externa - correct answer.acetic acid + propylene glycol + hydrocortisone
drops or
Cirpofloxacin + hydrocortisone drops

Otitis media - correct answer.-amoxicillin if <2 y/o
-analgesics if >2 with no pain or fever

Viral conjunctivitis - correct answer.nothing or chilled artificial tears

Bacterial conjunctivitis - correct answer.fluoroquinolone drops

Neonatal conjunctivitis with onset within 1st day of life - correct answer.nothing
Neonatal conjunctivitis with onset within 2-4 days of life - correct answer.IV
ceftriaxone
+ PO erythromycin
Neonatal conjunctivitis with onset within 3-10 days of life - correct answer.PO
erythromycin

Neonatal conjunctivitis with onset within 2-16 days of life - correct
answer.topical antivirals + IV acyclovir

Ophthalmia neonatorum prophylaxis - correct answer.tetracycline ointment or
erythromycin ointment

Post-antibiotic diarrhea - correct answer.Metronidazole

Travel associated diarrhea - correct answer.fluoroquinolone or rifaximin
-if a child or pregnant: azithromycin




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COMSAE
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COMSAE

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Uploaded on
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Written in
2025/2026
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