NURS 1234 - Exam 2 Study Guide.

NURS 1234 - Exam 2 Study Guide/NURS 1234 - Exam 2 Study Guide. Psychopharmacology Four sites of action o Receptors (Selectivity, Affinity, Intrinsic Activity) o Ion channels o Enzymes o Carrier proteins: uptake receptors Clinical concepts o Efficacy: the ability of a drug to produce a response o Potency: the dose of a drug required to produce a specific effect o Desensitization: a rapid decrease in drug effects that may develop in a few minutes of exposure to the drug o Tolerance: a gradual decrease in the action of a drug at a given dose or concentration o Toxicity: the point at which concentrations of the drug in the bloodstream are high enough to become harmful or poisonous to the body o Therapeutic index: the ration of the maximum nontoxic dose to the minimum effective dose Pharmacokinetics (how the body acts on the drug) o Absorption and routes of Admin o Distribution (solubility & protein binding) o Metabolism o Excretion Individual Variations in drug effects