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i-Human Week #9 High-Yield Question Exam: 69-Year-Old Patient with Back Pain - Complete Questions with Answers and Rationales

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This comprehensive document is a complete high-yield practice examination for a 69-year-old patient presenting with back pain, designed for i-Human or clinical reasoning assessments. It contains 100 multiple-choice questions with detailed answer rationales organized into four major sections: History & Review of Systems (questions 1-25) covering red flag assessment (night pain, unintentional weight loss, fever, night sweats, history of cancer, corticosteroid use, osteoporosis, IV drug use, trauma, urinary hesitancy, constipation, saddle anesthesia, pain characteristics including radicular pain, neurogenic claudication, Valsalva exacerbation, and morning stiffness), Physical Examination (questions 26-45) covering inspection (flexion posture, gait abnormalities), palpation (step-off deformity, spinous process tenderness), neurologic assessment (straight leg raise, crossed SLR, patellar/ankle reflexes, Babinski sign, heel/toe walking, perianal sensation, anal sphincter tone, abdominal reflexes, proximal muscle strength, and hip internal rotation), Differential Diagnosis (questions 46-55) covering mechanical low back pain, lumbar spinal stenosis, vertebral compression fracture, disc herniation, spinal metastasis, multiple myeloma, vertebral osteomyelitis/discitis, cauda equina syndrome, sacroiliitis, and inflammatory spondyloarthritis, and Diagnostics & Management (questions 56-100) covering imaging (X-ray, MRI without/with contrast, CT myelogram, bone scan, PET-CT), laboratory studies (CBC, ESR, CRP, procalcitonin, serum calcium, alkaline phosphatase, PSA, serum protein electrophoresis, Bence Jones protein, urinalysis), ECG for cardiac ischemia, emergent vs. urgent indications (cauda equina syndrome, progressive neurologic deficit, spinal cord compression), treatment strategies (analgesics, NSAIDs, opioids, bisphosphonates, denosumab, radiation therapy, IV antibiotics, epidural steroid injections, kyphoplasty, laminectomy, physical therapy, cognitive behavioral therapy, and conservative management), and clinical decision-making for older adults with back pain. Each question includes a clear rationale explaining the correct answer and why other options are incorrect, making this an essential study resource for medical, nursing, and advanced practice students preparing for clinical reasoning exams, i-Human cases, or primary care/geriatric medicine assessments.

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I-HUMAN WEEK #9 HIGH-YIELD QUESTION
EXAM FOR A 69-YEAR-OLD PATIENT WITH
BACK PAIN EXAM QUESTIONS AND ANSWERS
WITH RATIONALES LATEST UPDATE



• Each question is rationaled and correctly answered
• The questions cover history, physical exam, differential diagnosis, diagnostics (X-ray, ECG,
labs), and management—tailored to the outpatient clinic setting with the stated capabilities.




History & Review of Systems (Questions 1–25)

1.He reports morning stiffness lasting >1 hour. This points to:

• A) Mechanical back pain
• B) Inflammatory back pain (e.g., ankylosing spondylitis)
• C) Fibromyalgia
• D) Degenerative disc disease
Rationale: Prolonged morning stiffness is characteristic of inflammatory
spondyloarthropathies.

Answer: B

2. He takes no blood thinners. This is relevant because:

,• A) NSAIDs would be safer
• B) Epidural hematoma risk is lower
• C) He can safely have a spinal injection
• D) He does not need an INR check before X-ray
Rationale: In anticoagulated patients, spontaneous spinal epidural hematoma is a rare but
serious cause of back pain.

Answer: B

3. He has a history of osteoporosis. Most likely acute pathology:

• A) Disc herniation
• B) Vertebral compression fracture
• C) Spinal stenosis
• D) Muscle spasm
Rationale: Osteoporosis + back pain (even without trauma) = high risk for insufficiency fracture.
Answer: B

4. He denies IV drug use. This reduces suspicion for:

, A) Spinal metastasis
• B) Spinal epidural abscess
• C) Osteoporotic fracture
• D) Scheuermann’s disease
Rationale: IV drug use is a major risk factor for spinal epidural abscess (often
Staphylococcus aureus). Answer: B

5. Pain is midline lumbar rather than paraspinal. This suggests:

• A) Myofascial pain
• B) Vertebral body pathology
• C) Renal colic
• D) Sacroiliac joint pain
Rationale: Midline bony tenderness suggests vertebral body lesion (fracture, tumor, infection).
Answer: B

6. He reports recent corticosteroid use for COPD exacerbation. This increases risk for:

• A) Lumbar strain
• B) Avascular necrosis of spine (rare)
• C) Vertebral fracture
• D) Spinal stenosis
Rationale: Chronic/exogenous steroid use accelerates osteoporosis and fracture risk. Answer:
C

7.Pain is not relieved by lying down. This is concerning for:

• A) Mechanical cause
• B) Malignancy or infection
• C) Muscular strain
• D) Disc bulge
Rationale: Pain that persists recumbent is a red flag for neoplasm or infection. Answer: B

, 8.He reports fever of 101°F for 3 days. Most likely:

• A) Viral syndrome with back pain
• B) Vertebral osteomyelitis
• C) Polymyalgia rheumatica
• D) Degenerative disc disease
Rationale: Fever + back pain = infection (discitis/osteomyelitis) until proven. Answer: B

9. He has a history of multiple myeloma in a sibling. This increases risk for:

• A) Spinal stenosis
• B) Multiple myeloma (primary)
• C) Ankylosing spondylitis
• D) Paget’s disease
Rationale: Family history of multiple myeloma increases relative risk, though most cases are
sporadic. Answer: B

10.He reports pain radiating below the knee to the foot. This suggests:

• A) Lumbar radiculopathy
• B) Sacroiliac joint pain
• C) Greater trochanteric pain
• D) Facet arthropathy
Rationale: Pain radiating below knee (dermatomal pattern) = nerve root involvement. Answer:
A

11.He has no leg weakness but has reduced ankle reflex. Which nerve root?

• A) L3
• B) L4
• C) S1
• D) L5
Rationale: Ankle reflex (Achilles) is mediated by S1 nerve root.

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Number of pages
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Written in
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