NURS 5315 UTA Exam 2 Test Questions with Answers Graded A+
1. HIV EIA (3rd can use urine, saliva, or serum (most accurate), need to wait until 12 weeks post
generation im- exposure to see antibodies, >99% accurate
munoassay) 4th generation immunoassay- "gold standard"
measures P24 antigen
can test 10 days post exposure
2. Mast cell Cellular bags of granules located in loose connective tisssue close to blood
vessels. Activation initiates inflammatory process.
3. Histamine Causes vasodilation, increases vascular permeability, increases blood flow to the
site of injury- causes erythema and swelling.
4. Cytokines Soluble factors that contribute to the regulation of innate or adaptive resistance by
attecting other neighboring cells. Can be pro-inflammatory or anti-inflammatory.
Can react quickly or be more delayed.
5. Leukotrines Released when mast cells degranulate, prolong the inflammatory process. Cause
vasodilation, attract neutrophils, monocytes, and eosinophils.target of inhibition
for singular.
6. Prostaglandins Released when mast cells degranulate, are produced by the arachidonic pathway.
Cause vasodilation, platelet aggregation at site of injury, pain, and fever.
7. Chemotactic fac- Biochemical substance that attracts leukocyte to the site of inflammation
tors
8. Neutrophils Predominant leukocyte at work during the early stages of acute inflammation
9. Monocytes Become macrophages when entering the tissue, responsible for presenting anti-
gens to the CD4 cell which triggers T-cell immunity and B-cell immunity.
Releases additional cytokines IL1, IL6, TNF.
10. Cytokine IL1 Causes fever, activates phagocytes & lymphocytes and also increases the release
function of IL6a
, NURS 5315 UTA Exam 2 Test Questions with Answers Graded A+
11. Cytokine IL6 Stimulates production of acute phase reactants and promotes growth and stim-
function ulation of RBCs
12. Cytokine TNF Causes fever, increases synthesis of proinflammatory proteins by liver, causes
function muscle wasting, induces thrombosis
13. Cytokine growth Promotes production and maturation of neutrophils
factor function
14. Complement Functions include bacterial lysis, vasodilation and increased vascular permeability,
triggers mast cell degranulation, chemotaxis, and opsonization.
15. Kinin Converted to bradykinin which is responsible for pain and chemotaxis, and it
increases vascular permeability and vasodilation.
16. Coagulation cas- Factor XII activates kinin. Function is to form fibrin mesh to stop bleeding and trap
cade micro organisms.
17. COX1 Prostaglandin of arachidonic pathway. Provides gastroprotection, platelet aggre-
gation, fluid/electrolyte balance
18. COX2 Prostaglandin of arachidonic pathway. Responsible for pain, fever, renal protec-
tion, tissue repair, reproduction development.
19. COX2 inhibitors- Protect gastric mucosa- prevent ulcers and bleeding. Removed from market r/t
clinical implica- cardiac events except for Celebrex. Can impair renal function , monitor labs.
tions
20. Arachidonic Synthesis of prostaglandins
pathway purpose
21. Non-selective Inhibit COX1 and COX2, risk for gastric ulceration, GI bleeds, edema, renal impair-
NSAIDS ment
1. HIV EIA (3rd can use urine, saliva, or serum (most accurate), need to wait until 12 weeks post
generation im- exposure to see antibodies, >99% accurate
munoassay) 4th generation immunoassay- "gold standard"
measures P24 antigen
can test 10 days post exposure
2. Mast cell Cellular bags of granules located in loose connective tisssue close to blood
vessels. Activation initiates inflammatory process.
3. Histamine Causes vasodilation, increases vascular permeability, increases blood flow to the
site of injury- causes erythema and swelling.
4. Cytokines Soluble factors that contribute to the regulation of innate or adaptive resistance by
attecting other neighboring cells. Can be pro-inflammatory or anti-inflammatory.
Can react quickly or be more delayed.
5. Leukotrines Released when mast cells degranulate, prolong the inflammatory process. Cause
vasodilation, attract neutrophils, monocytes, and eosinophils.target of inhibition
for singular.
6. Prostaglandins Released when mast cells degranulate, are produced by the arachidonic pathway.
Cause vasodilation, platelet aggregation at site of injury, pain, and fever.
7. Chemotactic fac- Biochemical substance that attracts leukocyte to the site of inflammation
tors
8. Neutrophils Predominant leukocyte at work during the early stages of acute inflammation
9. Monocytes Become macrophages when entering the tissue, responsible for presenting anti-
gens to the CD4 cell which triggers T-cell immunity and B-cell immunity.
Releases additional cytokines IL1, IL6, TNF.
10. Cytokine IL1 Causes fever, activates phagocytes & lymphocytes and also increases the release
function of IL6a
, NURS 5315 UTA Exam 2 Test Questions with Answers Graded A+
11. Cytokine IL6 Stimulates production of acute phase reactants and promotes growth and stim-
function ulation of RBCs
12. Cytokine TNF Causes fever, increases synthesis of proinflammatory proteins by liver, causes
function muscle wasting, induces thrombosis
13. Cytokine growth Promotes production and maturation of neutrophils
factor function
14. Complement Functions include bacterial lysis, vasodilation and increased vascular permeability,
triggers mast cell degranulation, chemotaxis, and opsonization.
15. Kinin Converted to bradykinin which is responsible for pain and chemotaxis, and it
increases vascular permeability and vasodilation.
16. Coagulation cas- Factor XII activates kinin. Function is to form fibrin mesh to stop bleeding and trap
cade micro organisms.
17. COX1 Prostaglandin of arachidonic pathway. Provides gastroprotection, platelet aggre-
gation, fluid/electrolyte balance
18. COX2 Prostaglandin of arachidonic pathway. Responsible for pain, fever, renal protec-
tion, tissue repair, reproduction development.
19. COX2 inhibitors- Protect gastric mucosa- prevent ulcers and bleeding. Removed from market r/t
clinical implica- cardiac events except for Celebrex. Can impair renal function , monitor labs.
tions
20. Arachidonic Synthesis of prostaglandins
pathway purpose
21. Non-selective Inhibit COX1 and COX2, risk for gastric ulceration, GI bleeds, edema, renal impair-
NSAIDS ment
