Verifed Ace the Test
Medications for depression - ANSWER ✔✔SSRIs
SNRIs
SDRIs
TCAs
MAOIs
SSRIs - ANSWER ✔✔-Action: inhibit 5-HT reuptake
-Examples: citalopram, escitalopram, fluoxetine, paroxetine, sertraline
-Adverse effects:
,• nausea
• agitation
• diarrhea
• headache
• weight gain
• sexual side effects
SNRIs - ANSWER ✔✔-inhibit 5-HT reuptake
-inhibit NE reuptake (↑ energy, focus)
-increase DA in prefrontal cortex (↑ cognition)
-Examples: desvenlafaxine, duloxetine, levomilnacipran, venlafaxine
-Adverse effects:
• elevated blood pressure
• nausea
• sweating
• tremors
• anxiety
• insomnia
,• constipation
• anorexia
• sexual dysfunction
SDRIs - ANSWER ✔✔-inhibit DA reuptake (↑alertness, motivation)
-inhibit NE reuptake (↑energy)
-Adverse effects:
• agitation
• headache
• dry mouth
• constipation
• weight loss
TCAs - ANSWER ✔✔-Action: inhibits the reuptake of serotonin and
norepinephrine; blocks norepinephrine, histamine, and acetylcholine
receptors
-Examples: amitriptyline, clomipramine, desipramine, doxepin
-Common Side Effects:
• dry mouth
• constipation
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, • blurred vision
• urinary retention
• sedation
• weight gain
• hypotension
• tachycardia
• sexual dysfunction
MAOIs - ANSWER ✔✔-Action: increases norepinephrine and
serotonin by inhibiting the enzyme that inactivates it
-Examples: isocarboxazid, phenelzine, tranylcypromine
-Common Side Effects:
• sedation
• dizziness
• sexual dysfunction
• hypertensive crisis
Prescribing pearls: citalopram (Celexa) - ANSWER ✔✔mild
antihistamine effects