ANSWERS 2025
K dependent coagulation factors - CORRECT ANSWER -II, VII, IX, X
What inhibits vitamin K dependent coagulation factors? - CORRECT ANSWER -Warfarin (oral)
Factor VIII deficiency is also called - CORRECT ANSWER -Hemophilia A
Factor IX deficiency is also called - CORRECT ANSWER -Hemophilia B
What evaluates adequacy of fibrinogen in heparinized pts? - CORRECT ANSWER -RPR
von Willebrand factor - CORRECT ANSWER -
Mediate a bridge between glycoprotein complex on platelets and collagen on sub endothelial su
rface (defect can cause impaired platelet adhesion and aggregation)
Stuart-Prower factor - CORRECT ANSWER -X-
factor, is a part of cleaning prothrombin into thrombin
Hageman factor - CORRECT ANSWER -
Factor XII, is in the intrinsic pathway, activates Fletcher factor
Fletcher Factor - CORRECT ANSWER -Pre-K in intrinsic pathway and activates factor XI
Streptokinase - CORRECT ANSWER -Exogenous activator for plasminogen in fibrinolytic system
What is the end product of coagulation cascade? - CORRECT ANSWER -fibrin
,Intrinsic and common passway - CORRECT ANSWER -aPTT
extrinsic and common pathways - CORRECT ANSWER -PT
Average bleeding time - CORRECT ANSWER -1-7min
Common pathway factors - CORRECT ANSWER -X, V, II, I
extrinsic factors - CORRECT ANSWER -VII
intrinsic factors - CORRECT ANSWER -XII, XI, IX, VIII
Fibrinolysis - CORRECT ANSWER -dissolution of a clot
Primary homeostasis - CORRECT ANSWER -Formation of non-stable platelet plug
Secondary homeostasis - CORRECT ANSWER -Formation of durable fibrin strand
Most specific fibrinogen function test, not affected by heparin - CORRECT ANSWER -
thrombin time
Non-specific fibrinogen function test - CORRECT ANSWER -PT and PTT
VLDLB- CORRECT ANSWER -endogenous triglycerides transport
,Chylomicrons - CORRECT ANSWER -exogenous triglycerides transport
HDL and LDLB- CORRECT ANSWER -Cholesterol transport
adult hemoglobin - CORRECT ANSWER -2 alpha and 2 beta chains
fetal hemoglobin - CORRECT ANSWER -2 alpha and 2 gamma
Hemoglobin A2 - CORRECT ANSWER -2 alpha and 2 delta
Type I hypersensitivity - CORRECT ANSWER -IgE mediated
Type II hypersensitivity - CORRECT ANSWER -IgG
Type III hypersensitivity - CORRECT ANSWER -IgM and IgG
Heinz bodies lead to - CORRECT ANSWER -G6PD deficiency
Microangiopathic Hemolytic Anemia - CORRECT ANSWER -
Schistocytes ceratocytes and teardrop cells
Abetalipoproteinemia - CORRECT ANSWER -Acanthocytes
Beta Thalassemia - CORRECT ANSWER -target cells (codocytes)
Howell-Jolly bodies - CORRECT ANSWER -DNA
, Heinz bodies - CORRECT ANSWER -denatured hemoglobin
Papperheimer bodies - CORRECT ANSWER -Nonferritin iron
Dohle bodies - CORRECT ANSWER -Rrna in leukocytes
Alpha thalassemia minor - CORRECT ANSWER -two genes are defective
Alpha, thalassemia major - CORRECT ANSWER -four genes are defective
silent carrier of alpha thalassemia - CORRECT ANSWER -One gene is defective
Hemoglobin H disease - CORRECT ANSWER -3 a-genes deleted
-more likely asian
Immunoglobulin light chain consist of - CORRECT ANSWER -Kappa and lambda
Serum protein can be separated by cellulose acetate electrophoresis into 5 fractions -
CORRECT ANSWER -Albumin, alpha1 globulin, alpha2 globulin, beta globulin and delta globulin
Acutr hemolytic transfusion rxn - CORRECT ANSWER -
Hemoglobinemia, hemoglobinuria, hypertension
Hemoglobinuria - CORRECT ANSWER -excess hemoglobin in urine
adult bone marrow red cells most abundant - CORRECT ANSWER -Metamyelo (3-20%)