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Diphenhydramine (Benadryl) and Doxylamine (Unisom) -
✔✔ANSWER ✔✔-Two most common H1 antagonist
sleep aids
What are H1 antagonists used to treat in allergic
disorders? - ✔✔ANSWER ✔✔-Mild allergic reactions,
such as allergic rhinitis and urticaria.
What are the anticholinergic adverse effects of H1
antagonists? - ✔✔ANSWER ✔✔-Dry mouth and urinary
retention
,What depressive effects can H1 antagonists cause? -
✔✔ANSWER ✔✔-Sedation and impaired ability, more
common in FGA due to crossing the BBB
What behavioral adverse effects are associated with H1
antagonists? - ✔✔ANSWER ✔✔-Confusion and apathy
What stimulatory effects can H1 antagonists have? -
✔✔ANSWER ✔✔-Muscle spasm and appetite stimulation
What gastrointestinal adverse effects can occur with H1
antagonists? - ✔✔ANSWER ✔✔-Discomfort
What can happen at high doses of H1 antagonists? -
✔✔ANSWER ✔✔-CNS seizures and hallucinations
In which populations are H1 antagonists contraindicated?
- ✔✔ANSWER ✔✔-Newborns, children under the age of
2, and women who are breastfeeding.
,What conditions contraindicate the use of H1
antagonists? - ✔✔ANSWER ✔✔-Narrow-angle glaucoma,
prostatic hypertrophy, and acute exacerbation of
asthma.
What is the effect of H1 antagonists on allergic rhinitis? -
✔✔ANSWER ✔✔-Reduces sneezing, nasal discharge, and
irritation of the eyes, nose, and throat.
What is the mechanism of action (MOA) of H1
antagonists? - ✔✔ANSWER ✔✔-H1 antagonists work by
blocking H1 histamine receptors.
What effect do H1 antagonists have on histamine in the
body? - ✔✔ANSWER ✔✔-They help to reduce the effects
of histamine in the body.
How does blocking histamine action affect wakefulness?
- ✔✔ANSWER ✔✔-Blocking histamine action can lead to
sedation and help induce sleep.
, What is a common side effect of H1 antagonists when
used as a sleep aid? - ✔✔ANSWER ✔✔-Daytime
Drowsiness: Users may experience lingering sedation the
next day.
What are some anticholinergic effects of H1 antagonists?
- ✔✔ANSWER ✔✔-Dry mouth, blurred vision,
constipation, and urinary retention.
What CNS effects can H1 antagonists cause, particularly
in older adults? - ✔✔ANSWER ✔✔-Dizziness, confusion,
and incoordination.
What is the effect of H1 antagonists on urticaria? -
✔✔ANSWER ✔✔-Diminishes redness, itching, and
swelling.
Which first-generation H1 antagonists are effective for
motion sickness? - ✔✔ANSWER ✔✔-Promethazine and
dimenhydrinate.