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Antibiotics, Penicillins, Cephalosporins, Macrolides,
Tetracyclines, Antimicrobial Therapy, Drug Interactions,
Nursing Pharmacology and NCLEX Review Latest Updated
2026
What is beta-lactamase?
An enzyme that destroys penicillin
What is the priority action before starting antibiotic therapy?
Verify that the client does not have an allergy to an antibiotic.
Which statement accurately describes a broad spectrum antibiotic?
The antibiotic treats a wide variety of bacteria.
An antibiotic is prescribed based on which factors?
Laboratory testing
Most likely causative bacteria
,Client's symptoms
What causes penicillin resistance?
The production of beta-lactamase by the bacterial cell
When an antibiotic is bacteriostatic, it means what?
The antibiotic reduces the replication of the bacteria.
A client has been experiencing severe diarrhea for the last 2 weeks after completing a four-
week course of antibiotics. The diarrhea is best described as what?
Superinfection related to antibiotic use
A client is scheduled for a dental cleaning tomorrow and has been diagnosed with a heart
murmur in the past. The client's cardiologist prescribed azithromycin 500 mg orally x 1 dose
about 1 hour before the cleaning. Why is the client being prescribed this antibiotic?
Prophylactic treatment
How do antibiotics treat infection?
,Stop bacterial cell wall creation
Disrupt cell metabolism
Stop bacteria from producing proteins
1 multiple choice option
Amanda (pronouns: she/her/hers) was prescribed azithromycin 250 mg orally daily for 5 days.
She takes estradiol for birth control and uses warfarin 5 mg orally daily for chronic atrial
fibrillation. Which statement suggests that additional education is needed?
"My birth control will continue to be effective."
Which antibiotic class inhibits protein synthesis of the bacteria by binding to 50S ribosomal
subunits in the bacteria?
Macrolides
A client is taking erythromycin 500 mg orally three times daily for 10 days. What does the
nurse need to be concerned about while the client takes this drug?
Gastrointestinal (GI) upset
Nausea
Vomiting
1 multiple choice option
, A client is started on ciprofloxacin for symptoms of a urinary tract infection. They were seen
by a telemedicine provider and urine was not collected. Which statement is accurate about
the client's treatment?
The client is being treated empirically with the antibiotic.
A client started an antibiotic yesterday. Which assessment finding indicates an immediate
need to stop the antibiotic?
Rash
A client is prescribed tetracycline. Which drink taken with the medication would reduce the
absorption of tetracycline?
Milk
If a client has a penicillin allergy, what other antibiotic might they also react to?
Cephalosporins
A client was prescribed cefalexin for a skin infection. When should the client stop taking the
antibiotics?
When it says to on the prescription