Fungi
Cutaneous Mycoses
Tinea (dermatophytes) ● Trichophyton ● Require keratin for growth
● Epidermophyton (does not infect hair) ● Itching, scaling skin patches or plaque
● Microsporum (does not infect nails) ● Spread centrifugal → red border w/ central clearing
● Tinea pedis: athlete’s foot
● Tinea corporis: body
● Tinea capitis: head
● Tinea cruris: jock itch
● Tinea unguium: nails
● Tinea faciei: face
Tinea (pityriasis) versicolor ● Malassezia furfur ● Spaghetti & meatball (budding yeasts & curved pseudohyphae)
● Colonizes normal skin
● Loves lipid, damage melanocyte → hypo/hyperpigmentation of skin
Subcutaneous Mycoses
Dermis, Subcutaneous, Bone (almost always traumatic injury)
Sporotrichosis* ● Sporothrix schenckii ● Dimorphic; hyphae & clusters of conidia
● Rose gardener’s disease: isolate from soil, plant → direct inoculation
● Papule at puncture site → secondary lesions along lymphatics
● Yeast form = lesions in infected tissue
● Mycelial form = culture plate
● Sporothrix ฉึกๆ หนามกุหลาบ
Chromoblastomycosis ● Fonsecaea pedrosoi ● Scaly, nodular, tumorous warts & crusty abscess esp. lower extremities
(Chromomycosis) ● Cladophialophora carrionii ● Limited to skin & subcutaneous tissue
● Phialophora verrucosa ● Trauma then conidia enters
● Exophiala jeanselmei ● Muriform cells (copper penny)
Mycetoma ● Madurella mycetomatis ● Branching septate hyphae
● Madurella grisea ● Madura foot
● Actinomadura madurae ● Triad
1) Localized swelling
2) Draining sinuses
3) Colored grains (aggregates of infecting organisms)
● Eumycetoma: eukaryotic fungi ‘true” (Madurella, Phialophora, Aspergillus, etc.)
● Actinomycetoma: gram-positive filamentous bacteria “atypical” (Actinomadura, Nocardia)
● Surgical incision
Cutaneous Mycoses
Tinea (dermatophytes) ● Trichophyton ● Require keratin for growth
● Epidermophyton (does not infect hair) ● Itching, scaling skin patches or plaque
● Microsporum (does not infect nails) ● Spread centrifugal → red border w/ central clearing
● Tinea pedis: athlete’s foot
● Tinea corporis: body
● Tinea capitis: head
● Tinea cruris: jock itch
● Tinea unguium: nails
● Tinea faciei: face
Tinea (pityriasis) versicolor ● Malassezia furfur ● Spaghetti & meatball (budding yeasts & curved pseudohyphae)
● Colonizes normal skin
● Loves lipid, damage melanocyte → hypo/hyperpigmentation of skin
Subcutaneous Mycoses
Dermis, Subcutaneous, Bone (almost always traumatic injury)
Sporotrichosis* ● Sporothrix schenckii ● Dimorphic; hyphae & clusters of conidia
● Rose gardener’s disease: isolate from soil, plant → direct inoculation
● Papule at puncture site → secondary lesions along lymphatics
● Yeast form = lesions in infected tissue
● Mycelial form = culture plate
● Sporothrix ฉึกๆ หนามกุหลาบ
Chromoblastomycosis ● Fonsecaea pedrosoi ● Scaly, nodular, tumorous warts & crusty abscess esp. lower extremities
(Chromomycosis) ● Cladophialophora carrionii ● Limited to skin & subcutaneous tissue
● Phialophora verrucosa ● Trauma then conidia enters
● Exophiala jeanselmei ● Muriform cells (copper penny)
Mycetoma ● Madurella mycetomatis ● Branching septate hyphae
● Madurella grisea ● Madura foot
● Actinomadura madurae ● Triad
1) Localized swelling
2) Draining sinuses
3) Colored grains (aggregates of infecting organisms)
● Eumycetoma: eukaryotic fungi ‘true” (Madurella, Phialophora, Aspergillus, etc.)
● Actinomycetoma: gram-positive filamentous bacteria “atypical” (Actinomadura, Nocardia)
● Surgical incision
