NURS 615 Pharm_Exam 2 (2021) – Maryville University | NURS615 Pharm_Exam 2 (2020)

Law-Ham Pharm Exam 2 Review **Know every drug that is on the PowerPoint – have a one-line mechanism of action on a table for each drug and understand it, as well as how and where it works Carbamazepine (Tegretol) – is an anticonvulsant = thought to affect Na+ channels to slow spread of abnormal activity • SE = decreases body’s production of blood cells, rare reports of aplastic anemia and agranulocytosis, can cause Steven Johnson Syndrome and Toxic Epidermal Necrolysis • Should get a CBC Q3-4 months (watch for WBC count in particular) • Carbamazepine is a strong inducer of hepatic enzymes/metabolism and can lead to lower levels • Do NOT stop taking abruptly, has a shorter half-life w/repeated uses Topiramate (Topamax) – is for tx of epilepsy, seizures, migraine prophylaxis • Blocks sodium channels or potentiate GABA • Peaks 2 hours after oral admin, mostly eliminated via urine • Can cause ↓ Na bicarb levels which can lead to hyperchloremic metabolic acidosis • Serum bicarbonate should be monitored at baseline and periodically • Can cause ocular syndrome (acute myopia and glaucoma) – should inform provider immediately if pt experiences eye pain or blurred vision • Rare side effect is oligohidrosis (↓sweating) and hyperthermia • Can increase the risk of suicidal behavior/ideation, cause weight reduction • Should NOT be discontinued abruptly • Is a pregnancy category D and can increase risk of cleft lip/palate in infants