PSYCH 643 Study Guides Module 5: Depression, Psychopharmacology Study Guides - Regis College

PSYCH 643 Study Guides Module 5: Depression, Psychopharmacology Study Guides - Regis College Study Guide Module 5: Depression Familiarize yourself with theories of bipolar spectrum disorder and their criticism (Article: Bipolar Spectrum: A Critical Perspective) with consideration of the following: 1. Patient presentation rarely fits neatly into unipolar depression, bipolar I and bipolar II diagnostic criteria. 2. Treatment decisions can be guided by the bipolar spectrum classification. What are the 3 neurotransmitters most implicated in mood disorders? Serotonin, Dopamine, Norepinephrine Describe the synthesis of norepinephrine. Tyrosine Hydroxylase convert amino acid Tyrosine into DOPA, DOPA decarboxylase convert DOPA to DA, Dopamine b hydroxylase converts DA into NE How is norepinephrine metabolized? Monoamine oxidase (MAO) A or B, Catechol-o-methyl-transferase (COMT) What is the significance of presynaptic alpha-2 receptors? Presynaptic alpha 2 receptors are located in both the axon terminal and soma. Only a2 receptors can act as presynaptic autoreceptors, presynaptic alpha 2 receptors regulate norepinephrine release Describe how norepinephrine regulates serotonin. NE regulates 5HT neuros via alpha 1 and alpha 2 receptors, a1 accelerate and a2 brake