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Exam (elaborations) Pharmachology

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This is a Pharmacology exam elaboration concerning inhibitory amino acids (neurotransmission).

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Pharmachology Practice Quiz

Inhibitory Aminoacids

1. What is the main inhibitory neurotransmitter in the CNS (Central Nervous System)? Is
its concentration in the PNS (Peripherical Nervous System) high or low? Does it cross
the BBB (Blood-Brain Barrier)?
2. Explain the synthesis and storage of GABA. What is the limiting step? What is the
cofactor needed?
3. How does the finalization of the GABAergic neurotransmission occur?
4. What are the GABAergic receptors? Which ones are ionotropic and which ones are
metabotropic? Cite an agonist and an antagonist for each receptor.
5. What are the properties and neural functions related to the GABAergic system?
6. What effects can be expected by anti-epileptic drugs on the GABAergic
neurotransmission?
7. What is the main inhibitory neurotransmitter on the brainstem and on the spinal
cord? Mainly, how can it be synthetized? And what transporters mediate its
reuptake?
8. Cite an agonist and an antagonist of GlyR.
9. What are the physiological roles of glycine?

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