NABP
NAPLEX Exam
North American Pharmacist Licensure
Questions & Answers
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, Questions & Answers PDF Page 2
Version: 4.0
Question: 1
Which of the following represents the major route of metabolism for acetaminophen?
A. Glucuronidation
B. Sulfation
C. Cytochrome P-450 oxidation
D. Direct renal excretion
E. Plasma breakdown
Answer: A
Explanation:
Acetaminophen is metabolized by choices A through D. The major route is glucuronidation catalyzed
by UDP- glucuronyl transferase in the liver. Sulfation is the next most common route and is the target
mechanism for NAC therapy. Oxidation by cytochrome P-450 results in the formation of N-acetyl-p-
benzoquinone imine, which is responsible for the hepatic necrosis caused by acetaminophen
overdose. Direct renal excretion represents approximately 5% of the metabolism of acetaminophen.
Plasma metabolism of acetaminophen does not generally occur.
Question: 2
A 15-year-old presents with 6 days of nasal congestion with thin, clear rhinorrhe
a. She notes mild facial pain but has had no fevers. She feels her symptoms are improving.
What is the most likely cause of her symptoms?
A. Streptococcus pneumoniae
B. Viral
C. Moraxella catarrhalis
D. Haemophilus influenzae
E. Staphylococcus aureus
Answer: B
Explanation:
This patient shows symptoms of acute sinusitis. The most common etiology of which is viruses.
Indications that an infection is viral as opposed to bacterial included a shorter infection tie (less than
10 days) and no purulent discharge (hers is watery). She does not show any evidence of a
complication developing and even notes that her symptoms are improving. If her symptoms were
www.dumpstoday.com
NAPLEX Exam
North American Pharmacist Licensure
Questions & Answers
(Demo Version - Limited Content)
Thank you for Downloading NAPLEX exam PDF Demo
Get Full File:
https://dumpstoday.com/naplex-dumps/
, Questions & Answers PDF Page 2
Version: 4.0
Question: 1
Which of the following represents the major route of metabolism for acetaminophen?
A. Glucuronidation
B. Sulfation
C. Cytochrome P-450 oxidation
D. Direct renal excretion
E. Plasma breakdown
Answer: A
Explanation:
Acetaminophen is metabolized by choices A through D. The major route is glucuronidation catalyzed
by UDP- glucuronyl transferase in the liver. Sulfation is the next most common route and is the target
mechanism for NAC therapy. Oxidation by cytochrome P-450 results in the formation of N-acetyl-p-
benzoquinone imine, which is responsible for the hepatic necrosis caused by acetaminophen
overdose. Direct renal excretion represents approximately 5% of the metabolism of acetaminophen.
Plasma metabolism of acetaminophen does not generally occur.
Question: 2
A 15-year-old presents with 6 days of nasal congestion with thin, clear rhinorrhe
a. She notes mild facial pain but has had no fevers. She feels her symptoms are improving.
What is the most likely cause of her symptoms?
A. Streptococcus pneumoniae
B. Viral
C. Moraxella catarrhalis
D. Haemophilus influenzae
E. Staphylococcus aureus
Answer: B
Explanation:
This patient shows symptoms of acute sinusitis. The most common etiology of which is viruses.
Indications that an infection is viral as opposed to bacterial included a shorter infection tie (less than
10 days) and no purulent discharge (hers is watery). She does not show any evidence of a
complication developing and even notes that her symptoms are improving. If her symptoms were
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