Acute Pancreatitis
Normal Physiology 1
4171717T
T
ED
fwM088Ee 8088
Endocrinefunction PANCREATTIS
cagon and insulin into
jsegjgfeseag.nu
RfsWHEN
ACTIVATED EARLY
Exocrine Function Trypsinogen
that
sbeferedesdowdjgesdiareboejafrmaeifaomiyaagjj.ae singpfinEnerokinase
Lipids Lipases and protein proteases Zymogens Active
withinzymogen enzyme
Enzymesstored as Zymogens to protect granule
the Pancreas Trysin in the Duodenum ContainsProtease ACTIVE ENZYMES
qq.gq.iq
activated inhibitors toprevent INTHEPANCREAS
by Trysinogen will activate the breakdown CAUSEAUTODIGESTION
enzyme
OF PANCREATICCELLS
Pathophysiology
1 Alcohol induced 2 Gallstone Induced
9 Zymogen release from acinar cells Gallstone travels down CBD
fluid and bicarbonate in pancreatic and become lodged in the
ducts
µ sphincter of Oddi
Thick and sludgypancreaticjuices I
µ similar mechanism with
Blockage and backing up of juices backupof juices and early
leading to A ductal pressure activation of Trysin
tv
Distension and digestion of pancreatic
cells i.e
Autodigestion
Other causes I GET SMASHED
Idiopathic Steroids Hypercalcemia 1 Hypertriglyceridaemia
Gallstones Most Mumps ERCP
Autoimmune
Ethanol Common e gLupussiogrens Drugs e.g azathioprine Furosemide
Trauma e g stabs Scorpionsting Immunosuppressants
Normal Physiology 1
4171717T
T
ED
fwM088Ee 8088
Endocrinefunction PANCREATTIS
cagon and insulin into
jsegjgfeseag.nu
RfsWHEN
ACTIVATED EARLY
Exocrine Function Trypsinogen
that
sbeferedesdowdjgesdiareboejafrmaeifaomiyaagjj.ae singpfinEnerokinase
Lipids Lipases and protein proteases Zymogens Active
withinzymogen enzyme
Enzymesstored as Zymogens to protect granule
the Pancreas Trysin in the Duodenum ContainsProtease ACTIVE ENZYMES
qq.gq.iq
activated inhibitors toprevent INTHEPANCREAS
by Trysinogen will activate the breakdown CAUSEAUTODIGESTION
enzyme
OF PANCREATICCELLS
Pathophysiology
1 Alcohol induced 2 Gallstone Induced
9 Zymogen release from acinar cells Gallstone travels down CBD
fluid and bicarbonate in pancreatic and become lodged in the
ducts
µ sphincter of Oddi
Thick and sludgypancreaticjuices I
µ similar mechanism with
Blockage and backing up of juices backupof juices and early
leading to A ductal pressure activation of Trysin
tv
Distension and digestion of pancreatic
cells i.e
Autodigestion
Other causes I GET SMASHED
Idiopathic Steroids Hypercalcemia 1 Hypertriglyceridaemia
Gallstones Most Mumps ERCP
Autoimmune
Ethanol Common e gLupussiogrens Drugs e.g azathioprine Furosemide
Trauma e g stabs Scorpionsting Immunosuppressants
