ORAL CANCER &
*
Malignancy in oral cavity -
Staging =
•
Develop on
tongue
-
1 tissue mouths gums
L under lining
the
L Base oftongue
[ tongue
Throat
0 C .
odontogenic
carcinoma S a-
sarcoma .
malignancy
malig -
ORAL SQUAMOUS CELL CARCINOMA
a. K .
a Epidermoid carcinoma
-
most malignant neoplasm
An invasive epi neoplasm with
-
varying .
degrees of differentiation d
tendency to early
S extensive L .
N metastases main etio
-
-
Predominant = Alcohol ④ tobacco
usage
5th 16th decade adults
* Risk factors : - viral infxn ( Epstein-Barr )
-
poor OH -
autoimmune
-
Radiation -
trauma
-
genetic
* Floor of mouth → POOR prognosis
-
Clinical : -
White patch
features -
small exophytic growth
red erythematosus area Vary
|
-
-
small indolent ulcer ( ✗ heal ) -
Histopatho
-
toythwplakia . Invasion of tumor epi .
cell → C T-
-
Pain ( late stage ) . Islands + ve keratin pearls ( well def .
SCC )
* -
Induration o Invasive front ( invasion into muscles )
, , ,, ,µ , ,n , , no , , , , . ,nnn, , my
,ammaµy , ,ympn , , p ,, , ma ,
, , ,,,
-
underlying bone destruction a
Neo -
angionesis
* - L -
N t.ve •
Lymphatic 1 vascular metastasis
Advanced
A.•Histogradingdeteirmineprognosis
:
-
Broad base , rough nodular / warty exophy
tic mass Amount of keratiniza
Degree of
-
→ tion
-
Haemorrhagic / necrotic mass tumor cell
~
grading of tumour cell
like ulcer ( raises / diff
* Deeply destructive crater - .
-
rolled everted edges ) BRODER 'S CLASS
-
Pain speech Grade I ( w D) .
= low grade
Final disturbances f- trismus
Grade II ( M D)
dysphagia
- -
Grade III ( P D)
-
Bone destruction → tooth mobile
,
paresthesia .
=
High grade
trade IV ( Anaplastic tumours )
-
Distant metastases
, Differences of the Grade
1 2 3
Tumour Cell Population
"""" "" "" " " " "" "" "" "" "" " """" "" """ " ""
( Islands )
" www.amueraiin.m.o-oi.isomemai-inizati . " individual
*e.emia.in * ammonia . - •
*.ua. .me#n.a..n
in. *a.n.am
most cell resemble each other ; less moderate number of enlarged nuclei resemble
Nuclear
sm
polymorphi cell hardly ; numerous
Mode of invasion well defined
-
intermediate ,
less defined poor defined bcs cells present as sheets
vascular invasion Hardly show possibly Few
cellular
response High moderate slight
prognosis Gard moderate
poor
Most WD
-
* ofhey venous carcinoma -
concentric link formation
[
-
spindle cell \ keratin
( pearl
papillary
I Individual cell kevatinization
Adenosquamous -
(
Acautholytic
?⃝
?⃝
?⃝
*
Malignancy in oral cavity -
Staging =
•
Develop on
tongue
-
1 tissue mouths gums
L under lining
the
L Base oftongue
[ tongue
Throat
0 C .
odontogenic
carcinoma S a-
sarcoma .
malignancy
malig -
ORAL SQUAMOUS CELL CARCINOMA
a. K .
a Epidermoid carcinoma
-
most malignant neoplasm
An invasive epi neoplasm with
-
varying .
degrees of differentiation d
tendency to early
S extensive L .
N metastases main etio
-
-
Predominant = Alcohol ④ tobacco
usage
5th 16th decade adults
* Risk factors : - viral infxn ( Epstein-Barr )
-
poor OH -
autoimmune
-
Radiation -
trauma
-
genetic
* Floor of mouth → POOR prognosis
-
Clinical : -
White patch
features -
small exophytic growth
red erythematosus area Vary
|
-
-
small indolent ulcer ( ✗ heal ) -
Histopatho
-
toythwplakia . Invasion of tumor epi .
cell → C T-
-
Pain ( late stage ) . Islands + ve keratin pearls ( well def .
SCC )
* -
Induration o Invasive front ( invasion into muscles )
, , ,, ,µ , ,n , , no , , , , . ,nnn, , my
,ammaµy , ,ympn , , p ,, , ma ,
, , ,,,
-
underlying bone destruction a
Neo -
angionesis
* - L -
N t.ve •
Lymphatic 1 vascular metastasis
Advanced
A.•Histogradingdeteirmineprognosis
:
-
Broad base , rough nodular / warty exophy
tic mass Amount of keratiniza
Degree of
-
→ tion
-
Haemorrhagic / necrotic mass tumor cell
~
grading of tumour cell
like ulcer ( raises / diff
* Deeply destructive crater - .
-
rolled everted edges ) BRODER 'S CLASS
-
Pain speech Grade I ( w D) .
= low grade
Final disturbances f- trismus
Grade II ( M D)
dysphagia
- -
Grade III ( P D)
-
Bone destruction → tooth mobile
,
paresthesia .
=
High grade
trade IV ( Anaplastic tumours )
-
Distant metastases
, Differences of the Grade
1 2 3
Tumour Cell Population
"""" "" "" " " " "" "" "" "" "" " """" "" """ " ""
( Islands )
" www.amueraiin.m.o-oi.isomemai-inizati . " individual
*e.emia.in * ammonia . - •
*.ua. .me#n.a..n
in. *a.n.am
most cell resemble each other ; less moderate number of enlarged nuclei resemble
Nuclear
sm
polymorphi cell hardly ; numerous
Mode of invasion well defined
-
intermediate ,
less defined poor defined bcs cells present as sheets
vascular invasion Hardly show possibly Few
cellular
response High moderate slight
prognosis Gard moderate
poor
Most WD
-
* ofhey venous carcinoma -
concentric link formation
[
-
spindle cell \ keratin
( pearl
papillary
I Individual cell kevatinization
Adenosquamous -
(
Acautholytic
?⃝
?⃝
?⃝
