TEST PREP FOR
PHARMACOTHERAPUR
ICS and pharmacology
FOR ADVANCED
PRACTICE NURSE
PRESCRIBERS
2021/2022 REVISED
UPDATE
,Chapter 1. The Role of the Nurse Practitioner
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. Nurse practitioner prescriptive authority is regulated by:
1 The National Council of State Boards of Nursing
.
2 The U.S. Drug Enforcement Administration
.
3 The State Board of Nursing for each state
.
4 The State Board of Pharmacy
.
____ 2. The benefits to the patient of having an Advanced Practice Registered Nurse (APRN) prescriber include:
1 Nurses know more about Pharmacology than other prescribers because they take
. it both in their basic nursing program and in their APRN program.
2 Nurses care for the patient from a holistic approach and include the patient in
. decision making regarding their care.
3 APRNs are less likely to prescribe narcotics and other controlled substances.
.
4 APRNs are able to prescribe independently in all states, whereas a physician’s
. assistant needs to have a physician supervising their practice.
____ 3. Clinical judgment in prescribing includes:
1 Factoring in the cost to the patient of the medication prescribed
.
2 Always prescribing the newest medication available for the disease process
.
3 Handing out drug samples to poor patients
.
4 Prescribing all generic medications to cut costs
.
____ 4. Criteria for choosing an effective drug for a disorder include:
1. Asking the patient what drug they think would work best for them
2. Consulting nationally recognized guidelines for disease management
3. Prescribing medications that are available as samples before writing a
prescription
4. Following U.S. Drug Enforcement Administration guidelines for prescribing
____ 5. Nurse practitioner practice may thrive under health-care reform because of:
1 The demonstrated ability of nurse practitioners to control costs and improve
. patient outcomes
2 The fact that nurse practitioners will be able to practice independently
.
3 The fact that nurse practitioners will have full reimbursement under health-care
. reform
4 The ability to shift accountability for Medicaid to the state level
.
Chapter 2. Review of Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to prescribing because:
1 Distribution of drugs to target tissue may be affected.
.
, 2 The solubility of the drug will not match the site of absorption.
.
3 There will be less free drug available to generate an effect.
.
4 Drugs bound to albumin are readily excreted by the kidneys.
.
____ 2. Drugs that have a significant first-pass effect:
1 Must be given by the enteral (oral) route only
.
2 Bypass the hepatic circulation
.
3 Are rapidly metabolized by the liver and may have little if any desired action
.
4 Are converted by the liver to more active and fat-soluble forms
.
____ 3. The route of excretion of a volatile drug will likely be the:
1 Kidneys
.
2 Lungs
.
3 Bile and feces
.
4 Skin
.
____ 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage reservoir of the drug.
Storage reservoirs:
1 Assure that the drug will reach its intended target tissue
.
2 Are the reason for giving loading doses
.
3 Increase the length of time a drug is available and active
.
4 Are most common in collagen tissues
.
____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
1 Propensity to go to the target receptor
.
2 Biological half-life
.
3 Pharmacodynamics
.
4 Safety and side effects
.
____ 6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the prescription. This is
considered a loading dose. A loading dose:
1 Rapidly achieves drug levels in the therapeutic range
.
2 Requires four- to five-half-lives to attain
.
3 Is influenced by renal function
.
4 Is directly related to the drug circulating to the target tissues
.
____ 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the:
1 Minimum adverse effect level
.
2 Peak of action
, .
3 Onset of action
.
4 Therapeutic range
.
____ 8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
1 When the drug has a wide therapeutic range
.
2 When the drug will be administered for a short time only
.
3 When there is a high correlation between the dose and saturation of receptor sites
.
4 To determine if a drug is in the therapeutic range
.
____ 9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration. This means that
the:
1 Concentration will produce therapeutic effects
.
2 Concentration will produce an adverse response
.
3 Time between doses must be shortened
.
4 Duration of action of the drug is too long
.
____ 10. Drugs that are receptor agonists may demonstrate what property?
1 Irreversible binding to the drug receptor site
.
2 Upregulation with chronic use
.
3 Desensitization or downregulation with continuous use
.
4 Inverse relationship between drug concentration and drug action
.
____ 11. Drugs that are receptor antagonists, such as beta blockers, may cause:
1 Downregulation of the drug receptor
.
2 An exaggerated response if abruptly discontinued
.
3 Partial blockade of the effects of agonist drugs
.
4 An exaggerated response to competitive drug agonists
.
____ 12. Factors that affect gastric drug absorption include:
1 Liver enzyme activity
.
2 Protein-binding properties of the drug molecule
.
3 Lipid solubility of the drug
.
4 Ability to chew and swallow
.
____ 13. Drugs administered via IV:
1 Need to be lipid soluble in order to be easily absorbed
.
2 Begin distribution into the body immediately
.
3 Are easily absorbed if they are nonionized
.
PHARMACOTHERAPUR
ICS and pharmacology
FOR ADVANCED
PRACTICE NURSE
PRESCRIBERS
2021/2022 REVISED
UPDATE
,Chapter 1. The Role of the Nurse Practitioner
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. Nurse practitioner prescriptive authority is regulated by:
1 The National Council of State Boards of Nursing
.
2 The U.S. Drug Enforcement Administration
.
3 The State Board of Nursing for each state
.
4 The State Board of Pharmacy
.
____ 2. The benefits to the patient of having an Advanced Practice Registered Nurse (APRN) prescriber include:
1 Nurses know more about Pharmacology than other prescribers because they take
. it both in their basic nursing program and in their APRN program.
2 Nurses care for the patient from a holistic approach and include the patient in
. decision making regarding their care.
3 APRNs are less likely to prescribe narcotics and other controlled substances.
.
4 APRNs are able to prescribe independently in all states, whereas a physician’s
. assistant needs to have a physician supervising their practice.
____ 3. Clinical judgment in prescribing includes:
1 Factoring in the cost to the patient of the medication prescribed
.
2 Always prescribing the newest medication available for the disease process
.
3 Handing out drug samples to poor patients
.
4 Prescribing all generic medications to cut costs
.
____ 4. Criteria for choosing an effective drug for a disorder include:
1. Asking the patient what drug they think would work best for them
2. Consulting nationally recognized guidelines for disease management
3. Prescribing medications that are available as samples before writing a
prescription
4. Following U.S. Drug Enforcement Administration guidelines for prescribing
____ 5. Nurse practitioner practice may thrive under health-care reform because of:
1 The demonstrated ability of nurse practitioners to control costs and improve
. patient outcomes
2 The fact that nurse practitioners will be able to practice independently
.
3 The fact that nurse practitioners will have full reimbursement under health-care
. reform
4 The ability to shift accountability for Medicaid to the state level
.
Chapter 2. Review of Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to prescribing because:
1 Distribution of drugs to target tissue may be affected.
.
, 2 The solubility of the drug will not match the site of absorption.
.
3 There will be less free drug available to generate an effect.
.
4 Drugs bound to albumin are readily excreted by the kidneys.
.
____ 2. Drugs that have a significant first-pass effect:
1 Must be given by the enteral (oral) route only
.
2 Bypass the hepatic circulation
.
3 Are rapidly metabolized by the liver and may have little if any desired action
.
4 Are converted by the liver to more active and fat-soluble forms
.
____ 3. The route of excretion of a volatile drug will likely be the:
1 Kidneys
.
2 Lungs
.
3 Bile and feces
.
4 Skin
.
____ 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage reservoir of the drug.
Storage reservoirs:
1 Assure that the drug will reach its intended target tissue
.
2 Are the reason for giving loading doses
.
3 Increase the length of time a drug is available and active
.
4 Are most common in collagen tissues
.
____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
1 Propensity to go to the target receptor
.
2 Biological half-life
.
3 Pharmacodynamics
.
4 Safety and side effects
.
____ 6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the prescription. This is
considered a loading dose. A loading dose:
1 Rapidly achieves drug levels in the therapeutic range
.
2 Requires four- to five-half-lives to attain
.
3 Is influenced by renal function
.
4 Is directly related to the drug circulating to the target tissues
.
____ 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the:
1 Minimum adverse effect level
.
2 Peak of action
, .
3 Onset of action
.
4 Therapeutic range
.
____ 8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
1 When the drug has a wide therapeutic range
.
2 When the drug will be administered for a short time only
.
3 When there is a high correlation between the dose and saturation of receptor sites
.
4 To determine if a drug is in the therapeutic range
.
____ 9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration. This means that
the:
1 Concentration will produce therapeutic effects
.
2 Concentration will produce an adverse response
.
3 Time between doses must be shortened
.
4 Duration of action of the drug is too long
.
____ 10. Drugs that are receptor agonists may demonstrate what property?
1 Irreversible binding to the drug receptor site
.
2 Upregulation with chronic use
.
3 Desensitization or downregulation with continuous use
.
4 Inverse relationship between drug concentration and drug action
.
____ 11. Drugs that are receptor antagonists, such as beta blockers, may cause:
1 Downregulation of the drug receptor
.
2 An exaggerated response if abruptly discontinued
.
3 Partial blockade of the effects of agonist drugs
.
4 An exaggerated response to competitive drug agonists
.
____ 12. Factors that affect gastric drug absorption include:
1 Liver enzyme activity
.
2 Protein-binding properties of the drug molecule
.
3 Lipid solubility of the drug
.
4 Ability to chew and swallow
.
____ 13. Drugs administered via IV:
1 Need to be lipid soluble in order to be easily absorbed
.
2 Begin distribution into the body immediately
.
3 Are easily absorbed if they are nonionized
.
