ATI PHARMACOLOGY PROCTORED REMEDIATION STUDY GUIDE 2021

ATI PHARMACOLOGY PROCTORED REMEDIATION STUDY GUIDE Tumor lysis syndrome: When cancerous tumors break down very quickly, the kidneys have to work extra hard to remove all the substances that were in those tumors. If they can’t keep up, it can cause tumor lysis syndrome (TLS). Most common in people w/ blood-related cancers, including some leukemias & lymphomas. Occurs w/in a few hours to several days after a first chemotherapy tx. S/S: High levels of potassium can lead to neurological changes & heart problems. Excess uric acid (hyperuricemia) can cause kidney stones & kidney damage, can also develop uric acid deposits in joints, causing a painful condition similar to gout. A buildup of phosphate can lead to kidney failure. Too much phosphate can also cause calcium levels to drop, possibly leading to acute kidney failure. Hydroxyurea: (antimetabolites) tx psoriasis, chronic myelogenous leukemia (a cancer of the WBC’s), ovarian cancer, melanoma (a form of skin cancer), certain head & neck cancers, also helps w/ sickle cell anemia (an inherited blood disorder) by reducing the frequency of painful sickle cell crisis episodes & the need for blood transfusions. Hydroxyurea is sometimes used to treat polycythemia vera (a disorder of the bone marrow) by reducing the red blood cell mass. It works by slowing or stopping growth of cancer cells in body, & by helping to prevent the formation of abnormal red blood cells.Hydroxyurea toxicity:Hydroxyurea