PHARMACOLOGY OF
THE DIGESTIVE - CALCIUM CARBONATE ;
SYSTEM - the coated has good taste, well tolerated by
patients who need to use for longer;
1. DRUGS THAT ACT ON GASTRIC SECRETION; should be careful to associate aluminium or magnesium
hydroxide with calcium bicarbonate, as hydroxides
• NEUTRALISING ACID -> ACID;
neutralize the pH, and calcium is absorbed only in an
hydrochloric acid already formed; acidic environment;
acts immediately;
hydrochloric acid in the stomach has a lot of
ionisablehydrogen, and when administering this drug it • THAT INSTILL ACID SECRETION;
neutralizes -> are bases that react with hydrochloricacid
are not neutralizing; instill secretion!
gastrico, forming salt andwater;
antacids are not absorbed; the acid in the stomach - PROTON PUMP BLOCKERS;
interacts with the hydroxyl released by the drug;
- are sensitive to light; when the patient will
manipulate, thehere psula has to be colored to
- SOD IO BICARBONATE;
protect;
- rapid solubility, has immediate efficacy;
- irreversibly inreversibly the H+/K+-ATPase
- avoid prolonged use -> may generate
pump (pr3-tonepump), the terminal step inthe
hypernatremia;
secretiveroute ofcido;
- these medications are sensitive to PH acid ->
- MAGNESIUM HYDROXIDE ; need to reach the duodenum to be absorbed, if
- magnesiasio is absorbed only in the small it passes through the acidic pH of the stomach it
intestine and has an absorption limit -> the
is neutralized -> all another reason to coat the
excess goes into the large intestine -> the magnis
capsule!
unabsorbed
sio can cause
- ideal path:
diarrhea
they should be
osm ótica ->
absorbed
often used
into the
as laxative;
duodenum,re
- act faster than aluminum sais and neutralize acids ach
effectively;
thebloodstream,
stimulate the secretion of gastrin -> causing
thestomachpH to become more acidic -> after
- ALUMINUM HYDROXIDE; that, are activated in the parietal cells and
- aluminum relaxes the musculature -> delays release sulphic acid (this acid that inhibits
emptying, then "holds" the intestine; the prosthetic pump);
- Al(OH)3 slowly dissolves in the mage
when it blocks this pump, hydrogen does not release
to form hydrochloric acid! takes anaverage of 24
hours to form new pump;
should be used in fasting, because the presence of food
leaves the stomach more acidic, and before being
stooandgradually > relief; absorbed, these drugs are sensitive to the acid pH ->
- the association of magnissio and inactivates the drug;
aluminiumgenerates greater effectiveness -> Mg
acts fast and Al(OH)3 has prolonged relief; all can be administered orally and IV,except
rabeprazole, the oral administration of which is only
orally;
THE DIGESTIVE - CALCIUM CARBONATE ;
SYSTEM - the coated has good taste, well tolerated by
patients who need to use for longer;
1. DRUGS THAT ACT ON GASTRIC SECRETION; should be careful to associate aluminium or magnesium
hydroxide with calcium bicarbonate, as hydroxides
• NEUTRALISING ACID -> ACID;
neutralize the pH, and calcium is absorbed only in an
hydrochloric acid already formed; acidic environment;
acts immediately;
hydrochloric acid in the stomach has a lot of
ionisablehydrogen, and when administering this drug it • THAT INSTILL ACID SECRETION;
neutralizes -> are bases that react with hydrochloricacid
are not neutralizing; instill secretion!
gastrico, forming salt andwater;
antacids are not absorbed; the acid in the stomach - PROTON PUMP BLOCKERS;
interacts with the hydroxyl released by the drug;
- are sensitive to light; when the patient will
manipulate, thehere psula has to be colored to
- SOD IO BICARBONATE;
protect;
- rapid solubility, has immediate efficacy;
- irreversibly inreversibly the H+/K+-ATPase
- avoid prolonged use -> may generate
pump (pr3-tonepump), the terminal step inthe
hypernatremia;
secretiveroute ofcido;
- these medications are sensitive to PH acid ->
- MAGNESIUM HYDROXIDE ; need to reach the duodenum to be absorbed, if
- magnesiasio is absorbed only in the small it passes through the acidic pH of the stomach it
intestine and has an absorption limit -> the
is neutralized -> all another reason to coat the
excess goes into the large intestine -> the magnis
capsule!
unabsorbed
sio can cause
- ideal path:
diarrhea
they should be
osm ótica ->
absorbed
often used
into the
as laxative;
duodenum,re
- act faster than aluminum sais and neutralize acids ach
effectively;
thebloodstream,
stimulate the secretion of gastrin -> causing
thestomachpH to become more acidic -> after
- ALUMINUM HYDROXIDE; that, are activated in the parietal cells and
- aluminum relaxes the musculature -> delays release sulphic acid (this acid that inhibits
emptying, then "holds" the intestine; the prosthetic pump);
- Al(OH)3 slowly dissolves in the mage
when it blocks this pump, hydrogen does not release
to form hydrochloric acid! takes anaverage of 24
hours to form new pump;
should be used in fasting, because the presence of food
leaves the stomach more acidic, and before being
stooandgradually > relief; absorbed, these drugs are sensitive to the acid pH ->
- the association of magnissio and inactivates the drug;
aluminiumgenerates greater effectiveness -> Mg
acts fast and Al(OH)3 has prolonged relief; all can be administered orally and IV,except
rabeprazole, the oral administration of which is only
orally;
