Summary Pharmacology of Bronchial Asthma

BRONCHIAL ASTHMA- PHARMA
 Condition of Bronchial Hyperreactivity associated with
inflammation.
 Narrowing of air tubes, often accompanied by increased
secretion, mucosal oedema and mucus plugging.


TREATMENT APPROACH:
1. Prevention of antigen-antibody reaction.
2. Neutralization of IgE ( Omalizumab)
3. Supression of inflammation and Bronchial hyperactivity.
( Corticosteroids).
4. Prevention of release of Mediators ( Mast cells Stabilizers).
5. Antagonism of released mediators ( Antihistamines).
6. Blockade of constrictor NT ( Sympathomimetics).

 The only drugs effective for the treatment of acute attack of bronchial Asthma are
BRONCHODILATORS.






, CLASSIFICATIONS-
1. LEUKOTINE ANTAGONISTS-
 Montelukast
 Zafirlukast

2. MAST CELL STABILIZERS –
 Sod. Cromoglycate
 Ketotifen

3. CORTICOSTEROIDS –
 SYSTEMIC – Hydrocortisone, Prednisolone, Other Glucocoticoids.
 INHALATION- Beclomethasone, Dipropoinate, Budesonide, Fluticasone,
propionate, Flunisolide, Ciclesonide.

4. ANTI-IgE ANTIBODY –
 Omalizumab.

5. BRONCHODILATORS-
 B2 SYMPATHOMIMETICS
 Salbutamol
 Terbutaline
 Bambbuterol
 Salmeterol
 Formoterol
 METHYLXANTHINES
 Theophylline
 Aminophylline
 Choline
 Theophyllinate
 Hydroxyethyl
 Theophyyline
 Doxophylline

 ANTICHOLINERGICS
 Ipratropium Bromide
 Tiotropium Bromide