Our Lady of Fatima University
College of Pharmacy
Physical Pharmacy
Solubility of Drugs
Conclusion
As a result, I conclude that heat increases the solubility of sugar molecules since,
based on the results of the experiment, sugar heated to its boiling point dissolves faster
than sugar placed in water alone or sugar that hasn't reached its boiling point. To
elaborate, the increased energy in boiling water causes water molecules to travel faster.
This increased mobility allows the bonding between sucrose molecules simpler to break.
When it comes to the influence of other substances, salt dissolves faster with sugar than
it does by itself. Because the polar water molecules engage the oppositely charged polar
regions of the sucrose molecules and drag it off, the sucrose molecules then disintegrate.
Finally, based on the pH effect, I may infer that sugar does not dissolve in acidic solvents
such as vinegar because acids are incapable of breaking down carbohydrate, of which
sugar is an example. Furthermore, sugar dissolves in soapy water as well, but it takes a
long time to dissolve, implying that sugar in water dissolves the fastest of the three. This
is because energy is released when the somewhat polar sucrose molecules develop
intermolecular interactions with the polar water molecules. The energy required to
destabilize the structure of both the pure solute and the solvent is compensated for by
the weak bonds that form between the solute and the solvent.
Questions
1. Explain the factors affecting solubility of drugs? Give examples.
pH of fluid - This influences solubility in such a manner that increasing the pH results in
a decrease in solubility and the fraction of unionized form of a weakly basic medication,
as well as a rise in its distribution coefficient.
Examples:
- strong bases such as oxides and sulfides
- anion in the form of a conjugate base of a weak acid that may be protonated in solution
Temperature - This factor impacts solubility because as the temperature of a solution
rises, so does the average kinetic energy of the molecules in the solution. Due to the
obvious increase in kinetic energy, the solvent molecules could more thoroughly break
apart the solute molecules that are kept together by intermolecular interactions.
Examples:
- sugar and salt are more soluble in water at higher temperatures
- Ammonia gas declines solubility as temperature increases
Pressure - It influences solubility because, to a certain measure, the greater the
pressure above a liquid, the more gas that may be dissolved in that liquid. And since gas
solubility is pressure dependent, an increase in pressure enhances solubility while a
reduction in pressure reduces solubility.
College of Pharmacy
Physical Pharmacy
Solubility of Drugs
Conclusion
As a result, I conclude that heat increases the solubility of sugar molecules since,
based on the results of the experiment, sugar heated to its boiling point dissolves faster
than sugar placed in water alone or sugar that hasn't reached its boiling point. To
elaborate, the increased energy in boiling water causes water molecules to travel faster.
This increased mobility allows the bonding between sucrose molecules simpler to break.
When it comes to the influence of other substances, salt dissolves faster with sugar than
it does by itself. Because the polar water molecules engage the oppositely charged polar
regions of the sucrose molecules and drag it off, the sucrose molecules then disintegrate.
Finally, based on the pH effect, I may infer that sugar does not dissolve in acidic solvents
such as vinegar because acids are incapable of breaking down carbohydrate, of which
sugar is an example. Furthermore, sugar dissolves in soapy water as well, but it takes a
long time to dissolve, implying that sugar in water dissolves the fastest of the three. This
is because energy is released when the somewhat polar sucrose molecules develop
intermolecular interactions with the polar water molecules. The energy required to
destabilize the structure of both the pure solute and the solvent is compensated for by
the weak bonds that form between the solute and the solvent.
Questions
1. Explain the factors affecting solubility of drugs? Give examples.
pH of fluid - This influences solubility in such a manner that increasing the pH results in
a decrease in solubility and the fraction of unionized form of a weakly basic medication,
as well as a rise in its distribution coefficient.
Examples:
- strong bases such as oxides and sulfides
- anion in the form of a conjugate base of a weak acid that may be protonated in solution
Temperature - This factor impacts solubility because as the temperature of a solution
rises, so does the average kinetic energy of the molecules in the solution. Due to the
obvious increase in kinetic energy, the solvent molecules could more thoroughly break
apart the solute molecules that are kept together by intermolecular interactions.
Examples:
- sugar and salt are more soluble in water at higher temperatures
- Ammonia gas declines solubility as temperature increases
Pressure - It influences solubility because, to a certain measure, the greater the
pressure above a liquid, the more gas that may be dissolved in that liquid. And since gas
solubility is pressure dependent, an increase in pressure enhances solubility while a
reduction in pressure reduces solubility.
