Chapter 40: Disorders of Endocrine Function
Banasik: Pathophysiology, 6th Edition
MULTIPLE CHOICE
1. It is true that growth hormone excess in adults
a. results in the condition of acromegaly.
b. leads to abnormally tall stature.
c. is associated with hypoglycemia.
d. is usually asymptomatic.
ANS: A
Growth hormone excess in adults is known as acromegaly. Acromegaly in adults causes an
increase in bone density. Acromegaly may be clinically subtle and occurs with equal
frequency in men and women. Growth hormone in adults is not associated with
hypoglycemia.
2. An increase in ADH secretion occurs in response to
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er as
a. decreased serum osmolality.
b. dehydration.
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c. hypervolemia.
d. hyponatremia.
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ANS: B
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ADH is secreted in response to changes in blood osmolality. ADH increases membrane
permeability to and reabsorption of water. An increase in serum osmolality causes an
NURSinsufficient
increase in ADH secretion. With
INGTB.C OM of ADH, urine cannot be concentrated
amounts
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and free water is lost, causing hyperosmolality. Not enough salt outside the cells would not
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cause ADH to be secreted.
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3. Antidiuretic hormone (ADH) increases
a. sodium reabsorption in the distal tubule of the kidney.
b. potassium secretion in the distal tubule of the kidney.
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c. water reabsorption in the collecting tubule of the kidney.
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d. urinary output.
ANS: C
ADH acts directly on the renal collecting ducts and distal tubules, increasing membrane
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permeability to and reabsorption of water. Hypernatremia would be related to insufficient
amounts of ADH. ADH increases water reabsorption in the tubule of the kidney. With
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insufficient amounts of ADH, urine cannot be concentrated.
4. A clinical finding consistent with a diagnosis of syndrome of inappropriate ADH secretion
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(SIADH) is
a. hypovolemia.
b. hyponatremia.
c. decreased osmolality.
d. dehydration.
ANS: B
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, Pathophysiology 6th Edition Banasik Test Bank
SIADH is characterized by hyponatremia. Clinical manifestations of SIADH are as a result
of hypotonicity of body fluids. Serum osmolality is low because of dilution by reabsorbed
water. Inappropriate ADH secretion is not manifested by dehydration.
5. Diabetes insipidus is a condition that
a. results from inadequate ADH secretion.
b. is characterized by oliguria.
c. is associated with anterior pituitary dysfunction.
d. leads to glycosuria.
ANS: A
Diabetes insipidus is a condition related to insufficient ADH activity. Diabetes insipidus is
characterized by excessive loss of water in the urine. ADH is secreted by the posterior
pituitary gland. A hallmark of DI is the presence of excessive urination and excessive
drinking.
6. It is true that the synthesis of thyroid hormones
a. is increased by thyrotropin-inhibiting factor.
b. occurs in perifollicular C cells.
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er as
c. is stimulated by ACTH.
d. is inhibited by iodine deficiency.
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ANS: D
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Lack of iodine prevents production of both T4 and T3 but does not stop the formation of
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thyroglobulin. Thyroid hormone synthesis is not associated with thyrotropin-inhibiting
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factor. Perifollicular C cells are not responsible for thyroid hormone synthesis. Synthesis of
thyroid hormones does not occur through stimulation of ACTH.
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7. Clinical manifestations of Graves disease may include
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a. tremor.
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b. cold intolerance.
c. lethargy.
d. weight gain.
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ANS: A
Symptoms of Graves disease include restlessness, tremors, and irritability. Graves disease is
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associated with heat intolerance. Hyperthyroidism is associated with insomnia. Increased
basal metabolic rate may result in weight loss.
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8. It is true that Graves disease is
a. a secondary endocrine disorder.
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b. associated with autoantibodies to TSH receptors.
c. characterized by high serum TSH levels.
d. untreatable.
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ANS: B
Graves disease is an autoimmune disorder where autoantibodies cause the pituitary gland to
stop producing TSH. Graves disease is an autoimmune disorder. Serum TSH levels fall to
very low levels with Graves disease. Hyperthyroidism is treatable with medications,
surgery, or other modalities.
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