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Hepatitis

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PBL, Problem based learning of hepatitis case

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Medical
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Medical

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BLOCK 7 PBL 7– Hepatitis B Infection

Biological
1. Virulence factor of Hepatitis B virus




Morphology 1. Double-shelled spheres
2. Tubular structures
3. Smaller spherical structures
Open reading frames Surface proteins (S ORF)- encodes HBsAg
(ORFs) Core proteins (C ORF)- encodes HBcAg
Polymerase (P ORF)- encodes multifunctional polymerase
Hepatitis X protein (X ORF)- encode HBxAg

2. Classification of hepatitis virus
Virus Virus Viral Mode of Incubation Chronic Comments
classification genome infection period Hepatitis
Hepatitis A Hepatovirus ssRNA Fecal-oral 2-4 weeks No No carrier state
(HAV)
Hepatitis B Hepadnavirus dsDNA Blood-borne 6 weeks – Yes. Carriage associated with liver
(HBV) Sexual 6 months cancer
Hepatitis C Flavivirus ssRNA Blood-borne 2 months Yes Carriage associated with liver
(HCV) cancer
Hepatitis D Deltavirus ssRNA Blood-borne 2-12 weeks Yes Needs concurrent/ superinfect HBV
(HDV) infection
Hepatitis E Hepevirus ssRNA Fecal-oral 3-8 weeks No No carrier state
(HEV) Common in Far East




WEE 55484

, BLOCK 7 PBL 7– Hepatitis B Infection

3. Bilirubin metabolism




WEE 55484
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Uploaded on
January 14, 2022
Number of pages
10
Written in
2019/2020
Type
CASE
Professor(s)
Prof inn
Grade
A

Subjects

  • hepatitis
  • pbl
  • liver
  • medical
  • liver failure
  • cirrhosis
  • intravenous drug abuse
  • ivdu
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