SOLUTIONS
What cancer is the most frequently diagnosed in females?
Breast
Which ethnic group is more likely to develop breast ca?
Caucasians
What are some risk factors for breast ca?
-Increasing age
-Dense breast tissue
-Prolonged estrogen exposure (menarche <12yo, 1st term pregn >35yo, nulliparity, never
breastfeeding, contraceptives w/exogenous hormones, menopause >55yo, postmenopausal
hormone therapy)
-Fam h/o breast ca (esp. 1st degree relative)
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SOLUTIONS
-Personal h/o breast ca
-H/o benign breast dz (nonproliferative = slight risk, proliferative = high risk)
-Obesity in postmenopause
-Inherited gene mutations
-High dose radiation exposure to chest area at <20yo
->3 ETOH drinks/day
-Emerging/unclear risk factors (tobacco, phys. inactivity, high fat diet, night shift)
What are some assessment findings in breast ca?
-Painless, firm, fixed mass (most common symptom; no changes in mass w/menstruation)
-Nipple discharge that's not breast milk
-Skin/nipple changes (dimpling, skin ulceration, lymphedema, nipple retraction, scaly nipple
lesion or eczematous rash i.e. Paget's)
-Increased vascular pattern of breast
-Significant asymmetry of breasts
-Axillary, supraclavicular, infraclavicular lymph node enlargement
-Late findings: wt loss, anorexia, bone pain, anemia
What are some diff dx for breast ca?
-Breast cysts
-Fibroadenoma
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-Sclerosing adenosis
-Intraductal papilloma
-Hyperplasia
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-Radial scars
-Mastitis
What are some diagnostic studies for breast ca?
-Mammo
-US (differentiates fluid-filled cyst from solid mass)
-MRI
-Breast thermography (digital infrared thermal imaging)
-Fine needle or core bx
-Incisional or excisional bx
What are some preventions for breast ca?
-Screening (varies by expert organization)
-More frequent mammo or MRI for higher risk women
-Annual screening starting at 40yo (ACOG, ACOR, ACS, NCCN)
-Biennial screening 50-74yo (USPSTF)
If a woman has a breast mass but a normal mammo, what should be done?
NOT normal to have mass w/normal mammo; further imaging/eval needed.
What are some nonpharm options for breast ca?
-Genetic testing