Pathophysiology Chapter 30 Alterations of Leukocyte and Lymphoid Function

Pathophysiology Chapter 30 Alterations of Leukocyte and Lymphoid Function



1. In infectious mononucleosis (IM), what does the Monospot test detect?

a. Immunoglobulin E (IgE)

b. Immunoglobulin M (IgM)

c. Immunoglobulin G (IgG)

d. Immunoglobulin A (IgA)

2. A patient has been diagnosed with acute lymphocytic leukemia (ALL) and asks the

healthcare professional to describe it. What description by the professional is most accurate?

a. ALL is a progressive neoplasm defined by the presence of greater than 30%

lymphoblasts in the bone marrow or blood.

b. In ALL, immature blasts cells replace normal myelocytic cells, megakaryocytes,

and erythrocytes.

c. B cells fail to mature into plasma cells that synthesize immunoglobulins.

d. The translocation of genetic material from genes 9 and 22 create an abnormal, fused

gene identified as BCR-ABL.

3. Which description is consistent with chronic myelogenous leukemia (CML)?

a. Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the

gene encoding a cell-cycle regulatory protein.

b. Leukocytosis and a predominance of blast cells characterize the bone marrow and

peripheral blood. As the immature blasts increase, they replace normal myelocytic cells,

megakaryocytes, and erythrocytes.

c. B cells fail to mature into plasma cells that synthesize immunoglobulins.

d. The translocation of genetic material from genes 9 and 22 creates an abnormal,

fused protein identified as BCR-ABL1.